Tefillin use induces remote ischemic preconditioning pathways in healthy men

Owens, A. Phillip; Robbins, Nathan; Saum, Keith; Jones, Shannon; Kirschner, Akiva; Woo, Jessica G.; McCoy, Connie E; Slone, Samuel; Rothenberg, Marc E.; Urbina, Elaine M.; Tranter, Michael; Rubinstein, Jack

doi:10.1152/ajpheart.00347.2018

Cited by 6 publications

(3 citation statements)

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“…This clinical study was designed to use a HRV monitoring device on healthy human volunteers in order to determine if there was a correlation between our previous studies using tefillin [ 20 , 23 ] and changes in HRV parameters. Though we attempted to eliminate many stimuli that can affect HRV (exclusion criteria listed in Study Design), there are additional factors found in the literature that were not accounted for in this small preliminary study [ 33 , 34 , 46 , 47 ].…”

Section: Discussionmentioning

confidence: 99%

“…Our laboratory and others have investigated the RIPC effect in different animal [ 20 , 21 ] and human conditions [ 19 , 22 ] and have found that ischemia itself is not necessary to induce RIPC as the effect appears to be mediated by pain sensation and at least partially through transient potential receptor vanilloid (TRPV) channel stimulation [ 20 , 21 ]. Further, we have documented that the effect can be elicited by non-obstructive banding (NOB) of an extremity in healthy male individuals through the use of tefillin, which is a box with sacred texts attached to a leather strap that is traditionally bound to the non-dominant arm of Jewish adults during morning prayers [ 23 ]. The strap is usually worn for approximately 30 minutes in a manner that is tight enough to result in indentations in a helical manner on the skin of the arm and forearm but not tight enough to completely obstruct blood flow to the extremity.…”

Section: Introductionmentioning

confidence: 99%

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Tefillin use induces preconditioning associated changes in heart rate variability

et al. 2023

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Short bouts of occlusion of blood flow can induce a preconditioning response that reduces subsequent damage from longer periods of ischemia. It has been shown that ischemic preconditioning (IPC) can be elicited remotely (RIPC) through limitation of blood flow and as recently described via only pain sensation. Non-obstructive banding (NOB) through the donning of tefillin (a box with sacred texts attached to a leather strap that is traditionally bound to the non-dominant arm of Jewish adults during morning prayers) has been shown to elicit an RIPC response at least partially through pain sensation. This study evaluated the effects of NOB on heart rate variability (HRV) dependent factors that are known to be affected by various RIPC stimuli. We recruited 30 healthy subjects and subjected them to NOB versus control and found various HRV markers associated with RIPC to be changed in the NOB group. This finding provides further evidence that tefillin, likely through NOB induced RIPC changes, may still be a viable clinical pathway to prevent and decrease the morbidity associated with ischemic events.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Tefillin use induces preconditioning associated changes in heart rate variability

et al. 2023

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“…2 Observance of ultraorthodox Judaism includes a variety of observances some of which are listed in Table I . 3 , 4 , 5 , 6 , 7 , 8 The following patient case series addresses some of the rare dermatologic manifestations of Ashkenazi ultraorthodox Jewish observance throughout the life cycle. Ashkenazi Jews are those who are of Eastern European descent.…”

Section: Introductionmentioning

confidence: 99%