Ahstract-Benefiting from the popularity of computer game, Serious Game (SG) has been reaching a wide range of users. However, research on user interface design factors in SG for the Motor Impaired User (MIU) is still narrow, especially for the enjoyment experience context. This paper is aimed to proposed user interface design factors framework (SGameFlow) that makes MIU experience enjoyment when playing SG. This study is based on GameFlow Model to develop a rigorous user interface design factors that makes MIU experience enjoyment when playing SG. We make use of certain original model's factors together with three new factors (learning opportunities, accessibility and adaptivity) to predict user interface design factors of MIU enjoyment experience in SG.