Technique of Comparing Acute Toxicity in Infant vs. Adult Rats

RAYNSFORD, GAYL

doi:10.1001/archpedi.1963.02080040325001

Am J Dis Child

1963

DOI: 10.1001/archpedi.1963.02080040325001

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Technique of Comparing Acute Toxicity in Infant vs. Adult Rats

GAYL RAYNSFORD¹

Abstract: newborn animals is a relatively new concept.

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Cited by 8 publications

(1 citation statement)

References 4 publications

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“…The animal experiments with chloramphenicol demonstrated clearly that this drug was more toxic in the infant rat than in the adult. Animal toxicity studies corroborated the toxicity reported in infants (Kent et al, 1960; Michael et al, 1960; Raynsford, 1963).…”

Section: Effects Of Environmental Toxicants That Are Administered To supporting

confidence: 64%

Utilization of juvenile animal studies to determine the human effects and risks of environmental toxicants during postnatal developmental stages

Brent

¹

2004

Birth Defects Research Pt B

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Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.

“…The animal experiments with chloramphenicol demonstrated clearly that this drug was more toxic in the infant rat than in the adult. Animal toxicity studies corroborated the toxicity reported in infants (Kent et al, 1960; Michael et al, 1960; Raynsford, 1963).…”

Section: Effects Of Environmental Toxicants That Are Administered To supporting

confidence: 64%

Utilization of juvenile animal studies to determine the human effects and risks of environmental toxicants during postnatal developmental stages

Brent

¹

2004

Birth Defects Research Pt B

Get access via publisher Add to collection Cite

Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.

Acute toxicity of drugs in newborn animals

Yeary¹,

Benish²,

Finkelstein³

1966

The Journal of Pediatrics

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Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.

Teratogenicity and neonatal toxicity of clindamycin 2-phosphate in laboratory animals

Bollert

¹

,

Gray

²

,

Highstrete

³

et al. 1974

Toxicology and Applied Pharmacology

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Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.

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