Tear Hyperosmolarity in Renal Dialysis Patients Asymptomatic for Dry Eye

Charlton, Judie F.; Schwab, Ivan R.; Stuchell, Robert N.

doi:10.1097/00003226-199607000-00001

Cited by 32 publications

(35 citation statements)

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“…1,11 According to the previous studies, long-term HD can cause changes in the tear film and ocular surface. 1,18 An increased urea concentration in tears and decreased tear production after HD causes an increase in tear osmolarity. Hyperosmolarity stimulates inflammatory events in epithelial surface cells and the generation of inflammatory cytokines and matrix metalloproteinases (MMPs), which arise from or activate inflammatory cells at the ocular surface.…”

Section: Discussionmentioning

confidence: 99%

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Tear function in patients with chronic renal failure undergoing hemodialysis

et al. 2014

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Objectives: To evaluate dry eye symptoms and clinical tear film alterations in patients with chronic renal failure (CRF). Materials and methods: Thirty-five non-diabetic CRF patients undergoing hemodialysis, and 31 healthy individuals were enrolled. An ocular surface disease index questionnaire (OSDI) was administered, and after a complete ocular examination, Schirmer and tear break-up time (TBUT) tests were performed. Results: OSDI scores were significantly higher (p50.01) and TBUT tests were significantly lower (p ¼ 0.01) in CRF patients than in the control group. Schirmer test results were also lower in the CRF patients group, but lacked statistical significance (p ¼ 0.20). Conclusion: Patients with CRF should be advised to obtain an ophthalmic examination, especially for dry eye.

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Section: Discussionmentioning

confidence: 99%

“…This questionnaire has proved to be reliable for the assessment of dry eye symptoms. 18 After a complete ocular examination, including best-corrected visual acuity, slit-lamp and fundus examinations; Schirmer and tear break-up time (TBUT) tests were performed immediately prior to hemodialysis.…”

Section: Methodsmentioning

confidence: 99%

Tear function in patients with chronic renal failure undergoing hemodialysis

et al. 2014

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“…Metaplasia causes the conjunctiva to gradually develop into a nonsecretory keratinized Special Report epithelium, resulting in reduction in the mucin layer and then instability of the tear film. The duration of chronic renal failure has been demonstrated to directly affect the risk for squamous metaplasia [18] [20]. The authors proposed that the high levels of urea in the tears of patients on dialysis may be protective [20].…”

Section: Dry Eyementioning

confidence: 99%

“…The duration of chronic renal failure has been demonstrated to directly affect the risk for squamous metaplasia [18] [20]. The authors proposed that the high levels of urea in the tears of patients on dialysis may be protective [20].…”

Section: Dry Eyementioning

confidence: 99%

Ocular manifestations of chronic kidney disease among adult patients receiving hemodialysis

Okolo

Omoti²

2012

Expert Review of Ophthalmology

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“…HD usually induces changes in body fluid, thus affecting systemic blood pressure (BP) [20]. HD is associated with a wide range of ocular findings including refractive change, dry eye, increased tear osmolarity, lenticular opacity, and increased intraocular pressure [21][22][23][24]. Recently, a few studies have investigated the effect of HD on choroidal thickness (CT) [25][26][27].…”

Section: Introductionmentioning

confidence: 99%

Changes in Choroidal Thickness after Hemodialysis and the Influence of Diabetes

Kang

Choi²,

Kim

et al. 2017

J Retin

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Purpose:To evaluate the changes in subfoveal choroidal thickness (SFCT) after hemodialysis (HD) and to investigate the possible impact of diabetes mellitus (DM). Methods: This prospective, interventional case series included 18 patients undergoing HD due to chronic renal failure. Mean SFCT was measured before (pre-HD) and after HD (post-HD), and the differences (ΔSFCT) were calculated for each eye. In addition, the ratio of SFCT change (%SFCT; ΔSFCT/baseline SFCT × 100, percent, %) was calculated. Results: Ten patients (55.6%) had DM as the underlying etiology for HD. The mean SFCT was 311.8 ± 64.9 μm (177.5-468.0 μm) pre-HD and 311.2 ± 65.1 μm (191.5-454.5 μm) post-HD (p = 0.877). The mean ΔSFCT was -4.4 ± 20.0 μm (-64.0 to 29.0 μm), and the mean %SFCT was 4.3 ± 4.4% (0 to 19.5%). The mean ΔSFCT was significantly larger in patients with DM than those without DM (-14.1 ± 18.2 μm and 7.8 ± 15.6 μm; p = 0.006), but the mean %SFCT was not significantly different between the groups (4.4 ± 5.5% and 4.2 ± 2.6%; p = 0.315). Conclusions:The mean SFCT was not significantly changed after HD. The change in mean SFCT was significantly larger in patients with DM than in those without.

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Tear Hyperosmolarity in Renal Dialysis Patients Asymptomatic for Dry Eye

Cited by 32 publications

References 0 publications

Tear function in patients with chronic renal failure undergoing hemodialysis

Tear function in patients with chronic renal failure undergoing hemodialysis

Ocular manifestations of chronic kidney disease among adult patients receiving hemodialysis

Changes in Choroidal Thickness after Hemodialysis and the Influence of Diabetes

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