Tear changes in contact lens wearers following overnight eye closure

Abstract

Uncomplicated daily use of soft CLs does not appear to alter certain tear proteins compared with baseline levels. Uptake of these proteins by the CL does not appear to deplete the tear protein levels. Overnight levels of all tear proteins were increased, compared to daily CL wear.

Evidence of Lipid Degradation During Overnight Contact Lens Wear: Gas Chromatography Mass Spectrometry as the Diagnostic Tool

“…These characteristics, including the levels of tear proteins following overnight eye closure, with and without contact lens wear, have been investigated previously. [26][27][28] In these studies microcapillary tubes were used for tear collection immediately after opening the eye and changes in the levels of tear proteins were Copyright 2014 The Association for Research in Vision and Ophthalmology, Inc. www.iovs.org j ISSN: 1552-5783 measured. Microcapillary tear collection is a suitable method for aqueous tear collection; however, it is not ideal for tear lipid collection.…”

Quantification of protein deposits on silicone hydrogel materials using stable-isotopic labeling and multiple reaction monitoring

“…Major tear proteins consist of lysozyme (Fullard 1988), lactoferrin (Flanagan and Willcox 2009), albumin (Carney et al 1997), lipocalin (Glasgow et al 1995), IgA (Stapleton et al 1998) and phospholipase (Nevalainen et al 1994). Frequently detected tear proteins in contact lens extracts include lysozyme, lactoferrin, lipocalin, proline rich protein-4 and keratins (Zhao et al 2008;Emch and Nichols 2009).…”

Diurnal variation in group IIa phospholipase A2 content in tears of contact lens wearers and normal controls

“…According to some studies, the daily use of CLs has no effect on the amount of cells [10], total protein content [6,10,26], the content of sIgA [14], lysozyme [5,14], albumin [5,14] or lactoferrin [5] in tears. Furthermore, some studies have reported the tear sIgA content to increase due to the daily use of CLs [13,24,27] and another to decrease [12].…”

“…IgA isotypespecific antibodies reactive with Escherichia coli and Staphylococcus epidermidis have been reported to be present at lower levels in CL wearers than in normal subjects. In addition, the composition of tear proteins during the overnight use of CLs has been reported to change: both the total protein content and the C3, C4 and sIgA content of tears decreased after the overnight use of CLs [26].…”