Tea Nanoparticles for Immunostimulation and Chemo-Drug Delivery in Cancer Treatment

Yi, Sijia; Wang, Yongzhong; Huang, Yujian; Xia, Lijin; Sun, Leming; Lenaghan, Scott C.; Zhang, Mingjun

doi:10.1166/jbn.2014.1782

Cited by 36 publications

(39 citation statements)

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“…They stated that iron-chelation therapy, whether using synthetic or natural iron chelators as monotherapy or a combination, effectively modulates iron biochemistry and improves the status of antioxidant levels. Such treatments have been reported as a good therapy for many oxidant-antioxidant disturbances such as thalassemia(14), cancer(15), metabolic syndrome(12) and Parkinson’s disease(16). The study showed that staining in the cardiac organ has not shown hemosiderin pigment accumulation in the tissue.…”

Section: Discussionmentioning

confidence: 99%

Biochemical and histopathological effects of green tea nanoparticles in ironized mouse model

2017

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Transfusion in the treatment of thalassemia gives rise to iron deposits in many organs. Since there are many obstacles in the use of deferoxamin (DFO) as an iron chelating agent, it is important to find another alternative therapy that can act as iron chelation. The study aims to compare the histopathological pictures of the heart and spleen in iron-induced rats after administration of DFO and nanoparticles of green tea extract. The research used experimental research design with a post-test only control group. Experimental nano green teas were divided into four treatment groups; no diet, DFO supplementation, nano green tea supplementation, and a combination of both DFO and green tea. Ferritin and glutathione peroxides were used as biochemical parameters, and histopathological pictures of the heart and spleen were recorded. The study showed that there was significant improvement in the rats receiving DFO and nanoparticles of green tea compared with the rats in the no diet group. The study also reported that nano green tea has an effect comparable to DFO.

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Section: Discussionmentioning

confidence: 99%

Biochemical and histopathological effects of green tea nanoparticles in ironized mouse model

2017

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“…At the same time, in all types of the present samples, quercus suber botanical extract from the natural cork stoppers and silica from the succussed vial glassware walls could have further contributed, respectively, organic reducing and capping agents, quercus plant exosomes (nanoscale sized vesicles of plant proteins, nucleic acids, and lipids), silica NPs, as well as surface-stabilizing silica coats for other NPs in the samples. Leaching of the original natural cork into solution could have initiated this process [4,93,94].…”

Section: Nanotechnology Considerationsmentioning

confidence: 99%

Nanoparticle Characterization of Traditional Homeopathically-Manufactured Silver (Argentum Metallicum) Medicines and Placebo Controls

Muralidharan¹

2015

J Nanomed Nanotechnol

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This exploratory study characterized nanoparticles (NPs) in homeopathically-prepared silver medicine (Argentum Metallicum), succussed and unsuccussed control solutions. Methods included nanoparticle tracking analysis (NTA), zeta potentials, inductively-coupled plasma mass spectroscopy (ICP-MS) for silver, and ultraviolet visible spectroscopy (UV-vis). Homeopathy is a 200 year-old traditional medical system using mineral, plant, and animal sources to treat patients. Debate over the efficacy of homeopathic medicines (HMs) stems from its unique manufacturing methods involving dry milling in lactose and/or serial dilutions and succussions (intense agitation) in water or water-ethanol solvent. The present study examined commercially-made, randomized and blinded verum Argentum Metallicum HMs and succussed solvent controls at 6C, 30C, and 200C potencies, and unsuccussed solvent (95% v/v ethanol) in corkstoppered glass vials. NTA revealed >2 × 10 8 NPs/ml in 20 of 21 samples, with extensive polydispersity. Verum NP characteristics differed significantly from controls: (a) Although Verum 200C exhibited the highest NP concentrations and exemplar transmission electron microscopy of one Verum 30C sample showed scattered silver-like dark NPs embedded in an organic matrix, ICP-MS could not reliably detect elemental silver at 1 ppb (lower limits of instrument detection); (b) verum NPs were significantly larger sized across potencies (91 nm) versus unsuccussed controls (53 nm); (c) zeta potentials of verum NPs (mean-44 mV) were significantly more negative than the unsuccussed controls (mean-20 mV); (d) succussed controls were intermediate in NP concentrations and sizes between verums and unsuccussed controls; (e) All samples showed UV-vis absorbance peaks near 200-350 nm wavelengths, consistent with organic cork extract. Taken together, the findings suggest polydisperse heterogeneous nanohybrid mixtures of silver, silica shell/ silver core, silica NPs, and perhaps cork exosomes, self-assembled and surface-stabilized by silica coatings, organic plant extract (cork), and/or lactose in verums. Glassware-derived silica from succussions may contribute NPs and coatings for nonlinear source signal amplification to initiate clinical effects.

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“…There are several other doxorubicin-based nanoparticles have been documented and being getting investigated. 49–72 …”

Section: Introductionmentioning

confidence: 99%

Doxorubicin-Hyaluronan Conjugated Super-Paramagnetic Iron Oxide Nanoparticles (DOX-HA-SPION) Enhanced Cytoplasmic Uptake of Doxorubicin and Modulated Apoptosis, IL-6 Release and NF-kappaB Activity in Human MDA-MB-231 Breast Cancer Cells

Vyas¹,

Lopez-Hisijos²,

Gandhi³

et al. 2015

j nanosci nanotechnol

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Triple negative breast cancer exhibit increased IL-6 expression compared with matched healthy breast tissue and a strong link between inflammation and cancer progression and metastasis has been reported. We investigated whether doxorubicin-hyaluronan-super-paramagnetic iron oxide nanoparticles (DOX-HA-SPION) would show greater therapeutic efficacy in human triple negative breast cancer cells (TNBC) MDA-MB-231, as was recently shown in drug-sensitive and multidrug-resistant ovarian cancer cells. Therefore, we measured cellular DOX uptake via confocal microscopy; observed morphologic changes: mitochondrial and nuclear changes with electron microscopy, and quantitated apoptosis using FACS analysis after Annexin V and PI staining in MDA-MB-231 cells treated with either DOX alone or DOX-HA-SPION. We also measured both proinflammatory and anti-inflammatory cytokines; IL-6, IL-10 respectively and also measured nitrate levels in the conditioned medium by ELISA. Inaddition, NF-kB activity was measured by luciferase assay. Confocal microscopy demonstrated greater cytoplasmic uptake of DOX-HA-SPION than free DOX. We also demonstrated reduction of Vimentin with DOX-HA-SPION which is significantly less than both control and DOX. DOX-HA-SPION enhanced apoptosis and significantly down regulated both pro-inflammatory mediators IL-6 and NF-kB in comparison to DOX alone. The secretion levels of anti-inflammatory mediators IL-10 and nitrate was not decreased in the DOX or DOX-HA-SPION treatment groups. Our data suggest that DOX-HA-SPION nanomedicine-based drug delivery could have promising potential in treating metastasized and chemoresistant breast cancer by enhancing the drug efficacy and minimizing off-target effects.

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Tea Nanoparticles for Immunostimulation and Chemo-Drug Delivery in Cancer Treatment

Cited by 36 publications

References 0 publications

Biochemical and histopathological effects of green tea nanoparticles in ironized mouse model

Biochemical and histopathological effects of green tea nanoparticles in ironized mouse model

Nanoparticle Characterization of Traditional Homeopathically-Manufactured Silver (Argentum Metallicum) Medicines and Placebo Controls

Doxorubicin-Hyaluronan Conjugated Super-Paramagnetic Iron Oxide Nanoparticles (DOX-HA-SPION) Enhanced Cytoplasmic Uptake of Doxorubicin and Modulated Apoptosis, IL-6 Release and NF-kappaB Activity in Human MDA-MB-231 Breast Cancer Cells

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