volume 285, issue 9, P6826-6834 2010
DOI: 10.1074/jbc.m109.061846
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Chantelle F. Sephton, Shannon K. Good, Stan Atkin, Colleen M. Dewey, Paul Mayer, Joachim Herz, Gang Yu

Abstract: The gene coding TDP-43, 2 or TAR DNA-binding protein 43 (Tardbp), is highly conserved throughout evolution and is found in all higher eukaryotic species including distant species Drosophila melanogaster, Xenopus laevis, and Caenorhabditis elegans (1, 2). In humans, Tardbp is located at the chromosomal locus 1p36.22 and is comprised of six exons, five of which encode a ubiquitously expressed, predominantly nuclear, 43-kDa protein that contains two RNA recognition motifs and a glycine-rich C-terminal domain, ch…

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