TCF7L2 rs7903146 Gene Variation Is Associated with Risk of Type 2 Diabetes in Turkish Population

Demirsoy, İbrahim Halil

doi:10.4172/2472-128x.1000141

Cited by 8 publications

(8 citation statements)

References 24 publications

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“…Regarding genotype and allele frequencies of TCF7L2 (rs7903146), the T allele was signi cantly more represented in diabetic with complications than diabetic without complications, also TT and TC genotypes were signi cantly increased in diabetic without complications and diabetic with complications groups. This was in agreement with Nanfa et al, and Demirsoy et al, who reported that the T allele at rs7903146 was considerably related to the risk for diabetes [18,19]. Also, Buraczynska et al, reported that T allele was highly associated with DN [20].…”

Section: Discussionsupporting

confidence: 88%

“…The TCF7L2 gene has a vital role in the progression of T2DM by in uencing pancreatic islands, adipogenesis and myogenesis. It affects the beta cells function as well as granules accountable for insulin secretion and controls the expression of proteins tangled in insulin granules exocytosis [19]. Overexpression of TCF7L2 in human pancreatic islets was found to decrease glucose-stimulated insulin secretion.…”

Section: Discussionmentioning

confidence: 99%

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TCF7L2 gene polymorphism as a risk for type 2 diabetes mellitus and diabetic microvascular complications

Aboelkhair

Kasem

Abdelmoaty³

et al. 2021

Mol Biol Rep

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Background: Type 2 Diabetes Mellitus (T2DM) is a chronic metabolic condition with various genetics and environmental in uences that affects the capacity of the body to produce or use insulin resulting in hyperglycemia, which may lead to variable complications. It is one of the world's rising health problems.There is emerging evidence that some genetic polymorphisms can impact the risk of evolving T2DM.We try to determine the relationship of (rs7903146) variant of the Transcription factor 7-like 2 (TCF7L2) gene with T2DM and its microvascular complications.Methods and Results: This case-control study included 180 subjects: 60 diabetic patients without complications, 60 diabetic patients with microvascular complications and 60 matched healthy controls.Genotypes of rs7903146 (C/T) SNP in the TCF7L2 gene were evaluated by real-time polymerase chain reaction via TaqMan allelic discrimination. Logistic regression was used to detect the most independent factor for development of diabetes and diabetic microvascular complications. Variant homozygous TT and heterozygous TC genotypes were signi cantly increased in diabetic without complications and diabetic with complications groups than controls (p=0.003, 0.001) respectively. The T allele was more represented in both patient groups than controls with no signi cant difference between patient groups.TT genotype as well as T allele was signi cantly associated with increased T2DM risk. Conclusion:The T allele of rs7903146 polymorphism of TCF7L2 confers susceptibility to development of T2DM. However, no signi cant association was found for diabetic complications.

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Section: Discussionsupporting

confidence: 88%

Section: Discussionmentioning

confidence: 99%

TCF7L2 gene polymorphism as a risk for type 2 diabetes mellitus and diabetic microvascular complications

Aboelkhair

Kasem

Abdelmoaty³

et al. 2021

Mol Biol Rep

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“…34 The frequency of the risk allele in the HbA1c > 5.7 group was similar to the frequency described in women with a history of GDM in Greece and in other Caucasian and Indian 23 population studies, while it was higher compared to the frequency in East Asian populations where the T-allele was found to be usually occurring at levels less than 6%. The T-allele frequency was also lower than the levels reported in Turkish, 28 Arabic, Algerian (38-52%), 34 Brazilian (28-47,4%), 31 and African populations (36-46%) but was close to United Kingdom African Caribbean 23 and African American populations.…”

Section: In Acontrasting

confidence: 59%

“…21 Since the association between the TCF7L2 SNP rs7903146 and the risk of T2DM was first reported in a Genome Wide Association Study (GWAS) by Grant et al 22 numerous studies with the same approach 21 ) and case control studies replicated this association. The rs7903146 T-allele has been positively associated with risk for T2DM in European, 23 Indian, Thai, 24 and Iranian populations, 25 East Asian populations, namely, Japanese 26 and Chinese, 27 Turks, 28 Arabic, and Algerian, 29 African, 30 Brazilian, 31 and African American populations. 32 However, conflicting results have been reported in some studies in populations from China, Indonesia, 33 Saudi Arabia, and the United Arab Emirates, 34 Egypt, 35 as well as in a Native American population of North America, African Americans, Brazilian, 18 and Afro Caribbeans.…”

Section: Discussionmentioning

confidence: 99%

Interaction between TCF7L2 rs7903146 Genotype, HbA1c Levels, and the Periodontal Status of Dental Patients

et al. 2021

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Objective The aim of the study was to investigate the potential interaction between TCF7L2 rs7903146 genotype, which is implicated for type-2 diabetes mellitus genetic susceptibility, HbA1c levels, and the periodontal status of dental patients. Materials and Methods HbA1c levels, clinical periodontal parameters (probing depth, clinical attachment level, bleeding on probing, and plaque index), and several parameters (such as body mass index [BMI], smoking habits, education level, and age) were recorded in 150 patients who fulfilled the criteria for screening for prediabetes/diabetes of the Centers for Disease Control and Prevention. DNA was extracted and the TCF7L2 single nucleotide polymorphism (SNP) rs7903146 was genotyped in all participants. Results Thirty-one patients out of 150 tested were found with unknown hyperglycemia (20.7%). Regarding sex, education, parent with diabetes, normal BMI, smoking, age ≥45 years and prior testing for diabetes, no differences were observed between patients displaying HbA1c < 5.7 and ≥ 5.7% (Pearson’s Chi-square test, p > 0.05). Regarding periodontal parameters and differences between subgroups (HbA1c levels ≥ 5.7 and HbA1c levels < 5.7), statistically significant differences were observed for probing depth (3.20 ± 0.94 vs. 2.81 ± 0.78 mm), clinical attachment level (3.54 ± 1.20 vs. 3.18 ± 1.06 mm) and bleeding on probing (0.62 ± 0.25 vs. 0.50 ± 0.24%) with hyperglycemic patients exhibiting worse periodontal conditions (Mann–Whitney test p < 0.05). The allelic and genotype frequencies for the transcription factor 7-like 2 (TCF7L2) gene, SNPs 7903146 did not exhibit a significant difference between the HbA1c > 5.7 and HbA1c < 5.7 groups and the periodontitis and nonperiodontitis subgroups respectively (Fisher’s exact test >0.05). Statistical Analysis Patient characteristics and their association with prediabetes were tested by Pearson’s Chi-square test (asymptotic, two sided). Differences of periodontal parameters between subgroups were tested with the Mann–Whitney U-test. The associations of allele and genotype frequencies in the patient and control groups were analyzed using the Fisher’s exact test of independence.The significance level was set at the 0.05 for all tests. Conclusion A statistically significant association between TCF7L2 rs7903146 genotype and periodontal condition or HbA1c levels was not observed in contrast to statistically significant differences of clinical parameters of periodontitis in patients with hyperglycemia.

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“…Restriction fragment length polymorphism for rs7903146 (C/T) was carried out for the positive amplicons by digestion with the Hpy-CH4III enzyme at 37°C overnight, and the resulting products were electrophoresed on a 3% agarose gel. Digestion with Hpy-CH4III gave the following band patterns: 136 bp (mutant homozygote TT), 112 bp (wild homozygote GG), and 2 bands at 136 and 112 bp (heterozygotes GT), respectively [27, 28].…”

Section: Methodsmentioning

confidence: 99%

Role of Metabolic Risk Factors, Family History, and Genetic Polymorphisms (PPARγ and TCF7L2) on Type 2 Diabetes Mellitus Risk in an Asian Indian Population

Chaudhuri¹,

Das

Lodh³

et al. 2021

Public Health Genomics

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Introduction: Women with family history of diabetes (FHD) are at significantly increased risk of developing gestational diabetes mellitus which may eventually lead to type 2 diabetes mellitus (T2DM) in later life. Objective: This study investigates the role of FHD on metabolic markers and gene polymorphisms and hence on T2DM susceptibility in nondiabetic pregnant women and the subsequent risks in their newborns. Materials and Methods: The present study was conducted on 200 healthy (nondiabetic and normotensive) adult Asian Indian women, including 100 with and 100 without FHD, living in and around Kolkata, India. During the gestational period, they were studied twice and followed up till delivery. During delivery, both mothers’ venous blood and cord blood were collected to estimate serum CRP, glucose, and lipid profiles of the respective mothers and their newborns. Genotyping of PPARγ and TCF7L2 polymorphisms was done from these blood samples. Results: A comparison of the metabolic variables among the subjects with and without FHD revealed significant differences among them. We also found close relationship between mothers and their newborn babies in terms of both PPARγ (rs1801282) C/G and TCF7L2 (rs7903146) C/T polymorphisms. More specifically, genotyping results for mothers with FHD and their newborn babies showed high concordance in inheritance of alleles: (i) for PPARγ via the risk allele G (74.0%) which is carried over to the newborn babies (64.5%) and (ii) for TCF7L2 via the risk allele T (73.0%) which is carried over to the newborn babies (68.5%). Conclusion: This study leads to the conclusion that Asian Indian women population based in Kolkata, India, are ethnically and genetically predisposed to the risk factors of diabetes through FHD, which is reflected in their gestational phase, and it has a significant implication on their birth outcomes.

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TCF7L2 rs7903146 Gene Variation Is Associated with Risk of Type 2 Diabetes in Turkish Population

Cited by 8 publications

References 24 publications

TCF7L2 gene polymorphism as a risk for type 2 diabetes mellitus and diabetic microvascular complications

TCF7L2 gene polymorphism as a risk for type 2 diabetes mellitus and diabetic microvascular complications

Interaction between TCF7L2 rs7903146 Genotype, HbA1c Levels, and the Periodontal Status of Dental Patients

Role of Metabolic Risk Factors, Family History, and Genetic Polymorphisms (PPARγ and TCF7L2) on Type 2 Diabetes Mellitus Risk in an Asian Indian Population

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