Tcf7l2 Gene Polymorphism in T2dm with Patients in Turkish Population

doi:10.21767/2472-1158.100061

Cited by 2 publications

(2 citation statements)

References 21 publications

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“…Insulin resistance is the most pathological condition at which the cells in the target organs are unable to respond to normal serum insulin level [3]. T2DM making up about ninety percent of the diabetic subjects [4]. The etiology of type 2 diabetes mellitus clarify involvement of complex interactions between environmental and genetic factors [5].…”

Section: Introductionmentioning

confidence: 99%

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The Association of Resistin Gene –420c/G (Rs1862513) Single Nucleotide Polymorphism With Type Two Diabetes Mellitus in Iraqi Population

Hassan¹,

Ridha²,

Mohammed³

2019

Int. Res. J. Pharm.

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Background: Worldwide studies have shown polymorphisms within the resistin gene like-420C/G (rs1862513) to verify the effect of these polymorphisms in the occurrence of T2DM. Aim: To study the association of-420C/G with T2DM in Iraqi population. Methods: The study consisted of 400 T2DM patients and 400 healthy control individuals. Genotyping of-420C/G polymorphism is achieved by PCR-RFLP. DNA was extracted from whole blood and genotyping was carried out by specific primers to amplify fragments for digestion with restriction enzyme. Bbs I restriction enzyme used for digestion followed by electrophoresis on agarose gel. Various statistical analyses were used to analyze the data. Results: The genotype and allele frequencies of rs1862513 SNP revealed insignificant differences among the homo (GG) (OR= 1.42 ,CI 95%;0.95-2.11;P=0.08), hetero (CG) (OR= 1.07 CI 95%; 0.78-1.45, P= 0.7), dominant (OR = 1.42, CI 95%; 0.96-2.11, P= 0.08) and recessive (OR = 1.37, CI 95%; 0.96-1.98, P= 0.08) models. Furthermore, the minor allele frequency (G) was insignificantly increased (P= 0.21) in T2DM when compared with the control group. Conclusion: Resistin gene (rs1862513) polymorphism was exhibited non-significant association with T2DM in Iraqi population.

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Section: Introductionmentioning

confidence: 99%

“…This study aimed to estimate the association of -420 C/G SNPs with T2DM in Iraqi population. 4. They have an autoimmune disease (Rheumatic arthritis RA, cancers, infections, sever renal or liver disease, pregnancy or currently using glucocorticoid therapy.…”

Section: Introductionmentioning

confidence: 99%

The Association of Resistin Gene –420c/G (Rs1862513) Single Nucleotide Polymorphism With Type Two Diabetes Mellitus in Iraqi Population

Hassan¹,

Ridha²,

Mohammed³

2019

Int. Res. J. Pharm.

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Association of Neuropeptide-Y -399 (T/C) Gene Polymorphism and Its Level With the Risk of Type-2 Diabetes Mellitus

Elghobashy

Gayed

Zewin

2018

The Egyptian Journal of Biochemistry and Molecular Biology

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Neuropeptide-Y (NPY) is widely distributed centrally and peripherally and plays an important role in regulating glucose metabolism, energy metabolism and vascular function. Several studies had found that NPY is involved in the pathophysiology of type-2 diabetes Mellitus (T2DM). The aim of this study was to evaluate the association of NPY-399 (T/C) gene polymorphism and its serum level with susceptibility to T2DM. Seventy diabetic patients and seventy age and gender matched healthy controls were enrolled in this study. Serum NPY was measured by ELISA and NPY rs16147(-399 T/C) polymorphism was analyzed using the TaqMan allelic discrimination assay technique. Results showed significant statistical differences between the two studied groups regarding serum NPY level and NPY rs16147 (-399T/C) genotype distribution with increased serum NPY level and increased frequency of the CC and TC genotype in patients with diabetes mellitus. Conclusion: CC genotypes of NPY (-399 T/C) gene polymorphism and its associated high serum NPY level might be a genetic risk factor for T2DM.

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Tcf7l2 Gene Polymorphism in T2dm with Patients in Turkish Population

Cited by 2 publications

References 21 publications

The Association of Resistin Gene –420c/G (Rs1862513) Single Nucleotide Polymorphism With Type Two Diabetes Mellitus in Iraqi Population

The Association of Resistin Gene –420c/G (Rs1862513) Single Nucleotide Polymorphism With Type Two Diabetes Mellitus in Iraqi Population

Association of Neuropeptide-Y -399 (T/C) Gene Polymorphism and Its Level With the Risk of Type-2 Diabetes Mellitus

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