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Cited by 2 publications
(3 citation statements)
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References 8 publications
(9 reference statements)
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“…As previously mentioned, TC-PTP is primarily found in the cell nucleus due to a NLS in the C-terminus. However, we revealed that UVB irradiation triggers phosphorylation at the T179 residue of TC-PTP by AKT, which is required for the nuclear translocation of TC-PTP via 14-3-3σ, a protein critical to signal transduction and cell cycle regulation [ 139 , 140 ]. TC-PTP was also implicated in chemically induced skin carcinogenesis.…”
Section: T-cell Protein Tyrosine Phosphatasementioning
confidence: 99%
“…As previously mentioned, TC-PTP is primarily found in the cell nucleus due to a NLS in the C-terminus. However, we revealed that UVB irradiation triggers phosphorylation at the T179 residue of TC-PTP by AKT, which is required for the nuclear translocation of TC-PTP via 14-3-3σ, a protein critical to signal transduction and cell cycle regulation [ 139 , 140 ]. TC-PTP was also implicated in chemically induced skin carcinogenesis.…”
Section: T-cell Protein Tyrosine Phosphatasementioning
confidence: 99%
“…TC45 nuclear translocation accelerated nuclear signal transducer and activator of transcription 3 (STAT3) dephosphorylation, resulting in decreased cell proliferation and increased apoptosis. Disruption of 14‐3‐3σ/TC45 binding at T179 or loss of NLSII blocked UVB‐induced nuclear translocation, indicating both these sites are required for efficient nuclear translocation of TC45 upon UVB irradiation . Interestingly, Simoncic et al reported TC‐PTP was localized in the cytoplasm of hematopoietic cells as well.…”
Section: T‐cell Protein Tyrosine Phosphatase and Its Target Substratesmentioning
confidence: 62%
“…Disruption of 14-3-3σ/TC45 binding at T179 or loss of NLSII blocked UVB-induced nuclear translocation, indicating both these sites are required for efficient nuclear translocation of TC45 upon UVB irradiation. 24,25 Interestingly, Simoncic et al 26 reported TC-PTP was localized in the cytoplasm of hematopoietic cells as well. TC48, on the other hand, contains a hydrophobic C-terminus and is localized to the endoplasmic reticulum (ER).…”
Section: T-cell Protein Tyrosine Phosphatase and Its Target Substratesmentioning
confidence: 99%