Tc-99m MIBI Uptake and Its Relation to the Proliferative Potential of Brain Tumors

Ak, İlknur; Gülbaş, Zafer; Altınel, Faruk; Vardareli̇, Erkan

doi:10.1097/00003072-200301000-00007

Cited by 32 publications

(25 citation statements)

References 12 publications

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“…No study has examined the uptake mechanism of Tc-99m MIBI in parathyroid carcinoma. Related studies suggest that intense uptake and delayed retention may be caused by high mitochondrial content, increased perfusion, or increased metabolic activity [25][26][27].…”

Section: Discussionmentioning

confidence: 99%

Differential Findings of Tc-99m Sestamibi Dual-Phase Parathyroid Scintigraphy Between Benign and Malignant Parathyroid Lesions in Patients with Primary Hyperparathyroidism

Cheon

Choi

Chung

et al. 2011

Nucl Med Mol Imaging

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Section: Discussionmentioning

confidence: 99%

Differential Findings of Tc-99m Sestamibi Dual-Phase Parathyroid Scintigraphy Between Benign and Malignant Parathyroid Lesions in Patients with Primary Hyperparathyroidism

Cheon

Choi

Chung

et al. 2011

Nucl Med Mol Imaging

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“…In previous studies, higher tracer uptake by glioma on SPECT was shown to be associated with higher grade and decreased response to chemotherapy of gliomas (11)(12)(13)(14). In addition, higher technetium-99m-methoxyisobutylisonitrile ( 99m Tc-MIBI) uptake was demonstrated to correlate with higher proliferative potential of gliomas and with worse survival (15)(16)(17)(18)(19). However, to the best of our knowledge, previous studies employed SPECT scans only once during the treatment period and currently there are no studies evaluating the association of repeated SPECT scans during perioperative periods with the prognosis of malignant glioma patients.…”

Section: Introductionmentioning

confidence: 95%

Perioperative single photon emission computed tomography in predicting survival of malignant glioma patients

et al. 2012

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Abstract. Single photon emission computed tomography (SPECT) is widely used in the evaluation of glioma patients and has been demonstrated to correlate with glioma malignancy and proliferation indexes. The aim of this study was to evaluate the association between perioperative technetium-99m-methoxyisobutylisonitrile ( 99m Tc-MIBI) uptake on SPECT scans and survival of malignant glioma patients. A total of 17 patients (11 males and 6 women; mean age, 62.2±8.4 years) with histologically confirmed malignant gliomas (16 glioblastoma multiforme and 1 gliosarcoma) underwent 99m Tc-MIBI SPECT scans 2.8±1.9 days before surgery and 9.8±1.5 days after surgery. The total intensity index (TII) that corresponds to the area and intensity of tracer uptake was calculated before and after surgery. In addition, the change of TII before versus after surgery (Δ TII) was calculated. The overall survival (OS) was defined as the period between the date of surgery and the date of death. The median overall survival time was 12.4 months, ranging from 1.4 to 88 months; there were nine (45%) 12-month survivors. In univariate analyses using a log-rank test, worse OS was significantly associated with higher preoperative TII (≥12), higher postoperative TII (≥6), lower Δ TII (<50%) and higher number of neurological symptoms prior to surgery (≥4). In multivariate analyses, higher postoperative TII, a greater number of neurological symptoms and female gender were found to be factors with independent prognostic value of OS. Patients who survived more than 12 months following surgery had a significantly lower postoperative TII, higher Δ TII and greater rate of gross total resection compared to patients who survived less than 12 months following surgery. Higher perioperative tracer uptake and lower decrease of tracer uptake following surgery (suggesting less radical resection) were associated with worse OS of malignant glioma patients. Our results suggest that SPECT may be used to predict survival of malignant glioma patients; however, further studies using larger samples are required.

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“…Baillet and Ak have studies on 99mTc-sestamibi. They proved the relation of increased tracer uptake in high aneauploidi of DNA in tumor and so high degree of malignancy (1,3). Another study showed 99mTc-sestamibi SPECT has 73% sensitivity and 85% specifity (11).…”

Section: Discussionmentioning

confidence: 97%

Radiological and scintigraphic evaluation versus stereotaxic biopsy for intracranial hypodense lesions: a comparison study

Kutlay

Kaya²,

Topuz³

et al. 2009

Turkish Neurosurgery

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AIM:Intracranial hypodense lesions include a wide group of pathologies with different structures and characters. Although the radiological imaging properties of these neoplastic and non-neoplastic lesions are similar, treatment modalities for each lesion differs due to histopathological structure. MATERIAL and METHODS:In this study we have compared the results of radiological and scintigraphic evaluations with the results of stereotaxic biopsies to figure out the diagnostic impact of these non-inasive modalities. 16 patients who admitted to outpatient clinics with headache and/or seizure complaints were included in the study. RESULTS:MR spectroscopic images diagnosed the lesions as accurately as stereotaxic biopsies. CONCLUSION:Although stereotaxic biopsy keeps the label of "gold standard" when establishing a diagnosis for these lesions, modern radiological modalities are quite reliable.

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Tc-99m MIBI Uptake and Its Relation to the Proliferative Potential of Brain Tumors

Cited by 32 publications

References 12 publications

Differential Findings of Tc-99m Sestamibi Dual-Phase Parathyroid Scintigraphy Between Benign and Malignant Parathyroid Lesions in Patients with Primary Hyperparathyroidism

Differential Findings of Tc-99m Sestamibi Dual-Phase Parathyroid Scintigraphy Between Benign and Malignant Parathyroid Lesions in Patients with Primary Hyperparathyroidism

Perioperative single photon emission computed tomography in predicting survival of malignant glioma patients

Radiological and scintigraphic evaluation versus stereotaxic biopsy for intracranial hypodense lesions: a comparison study

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