2018
DOI: 10.1002/jlb.6a0918-339r
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Abstract: TBX21‐1993T/C (rs4794067) polymorphism increases the transcriptional activity of the Tbx21, essential for interferon gamma (IFNg) transcription, but its functional impact on development Th1‐ response in vivo remains unclear, as well its potential influence over inflammatory osteolytic conditions, such as periapical lesions. Therefore, this study comprises a case‐control and functional investigation of Tbx21 genetic variations impact on Th1 response in vivo and in vitro, and its impact on periapical lesions ris… Show more

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Cited by 5 publications
(7 citation statements)
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References 54 publications
(153 reference statements)
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“…Conversely, chronic gingivitis samples (from patients with a clinical history of gingival inflammation without significant bone loss) show a predominant RANKL < OPG profile, suggestive of lesion stability (Menezes et al 2008). In this context, considering the aforementioned restrictions regarding long-term longitudinal studies, the analysis of short-term responsiveness/unresponsiveness to periodontal therapy may comprise a convenient indicator of lesion phenotype (Menezes et al 2008; Dutzan, Vernal, et al 2009; Colavite et al 2019). Periapical granuloma samples also present variable RANKL/OPG ratio profiles, suggestive of the existence of both progressive and stable lesions (Menezes et al 2008; de Campos Soriani Azevedo et al 2019).…”
Section: Lesion Progression Patterns: Evidence From Clinical and Labomentioning
confidence: 99%
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“…Conversely, chronic gingivitis samples (from patients with a clinical history of gingival inflammation without significant bone loss) show a predominant RANKL < OPG profile, suggestive of lesion stability (Menezes et al 2008). In this context, considering the aforementioned restrictions regarding long-term longitudinal studies, the analysis of short-term responsiveness/unresponsiveness to periodontal therapy may comprise a convenient indicator of lesion phenotype (Menezes et al 2008; Dutzan, Vernal, et al 2009; Colavite et al 2019). Periapical granuloma samples also present variable RANKL/OPG ratio profiles, suggestive of the existence of both progressive and stable lesions (Menezes et al 2008; de Campos Soriani Azevedo et al 2019).…”
Section: Lesion Progression Patterns: Evidence From Clinical and Labomentioning
confidence: 99%
“…Thus far, most of the studies in the field have focused on individual cytokines or cell types, and their potential interplay in the determination of lesion progression remains unclear. Interestingly, when human periapical lesions are stratified based on RANKL/OPG ratio, the association of proinflammatory cytokines with high RANKL levels in the putative active clusters in evidenced by associative and mechanistic studies (Araujo-Pires, Francisconi, et al 2014; Colavite et al 2019; de Campos Soriani Azevedo et al 2019). IFN-γ and IL17 were independently associated with increased RANKL expression in distinct Th1 and Th17 clusters, suggesting that each subset individually mediates lesion progression (Araujo-Pires, Francisconi, et al 2014; Colavite et al 2019; de Campos Soriani Azevedo et al 2019).…”
Section: Host Response Determinants Of Lesion Progression and Stabilitymentioning
confidence: 99%
“…[26][27][28] Such data can provide a theoretical cutoff or threshold value that distinguish presence of absence of active bone resorption, which can be applied to periodontitis or other inflammatory osteolytic conditions, such as periapical lesions, to support additional analysis or assumptions. 22,29,30 In an additional example on how the use of distinct phenotypes can provide "biological significance" that upregulated in diseased tissues when compared with healthy ones, associated with a "very significative" P value (P<0.001). 32 Similarly to previously mentioned to OPG and anti-inflammatory mediators, one could argue how increased levels of inflammation suppressors, associated to "highly significative" P values (in healthy vs diseased tissues comparison), are presented in inflamed and diseased periodontal sites?…”
mentioning
confidence: 99%
“…21,32 Also, similar patterns (positive correlations between IL-10 and OPG) were observed when lesions are stratified as theoretically active of inactive based in RANKL/ OPG threshold, being IL-10 and OPG expression predominant in inactive lesions. 22,29,30,33 Moreover, when biological events are evaluated such as those mentioned above, it may be naive to trust that a single independent variable would be To P or not to P, is that the question? Rethinking experimental design and data analysis to improve biological significance beyond the statistical significance J Appl Oral Sci.…”
mentioning
confidence: 99%
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