Tazarotene Is an Effective Therapy for Elastosis Perforans Serpiginosa

Outland, J. David; Brown, Timothy S.; Callen, Jeffrey P.

doi:10.1001/archderm.138.2.169

Cited by 45 publications

(35 citation statements)

References 9 publications

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“…3 Laser resurfacing was found to be beneficial in some patients, 4 and cellophane tape stripping 5 is sometimes helpful. However, topical or intralesional corticosteroids 2 and curettage and electrodesiccation 6 are ineffective.…”

Section: Therapeutic Challengementioning

confidence: 99%

Imiquimod Therapy for Elastosis Perforans Serpiginosa

Kelly

Purcell²

2006

Arch Dermatol

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Section: Therapeutic Challengementioning

confidence: 99%

Imiquimod Therapy for Elastosis Perforans Serpiginosa

Kelly

Purcell²

2006

Arch Dermatol

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“…The moderately effective treatments include cryotherapy, cellophane tape stripping and oral isotretinoin. There have been some recent reports of successful outcomes after using tazarotene gel 14 and imiquimod cream 15 . We have used various methods, including a CO2 laser to resurface the lesions and a tretinoin cream, but those induced only a partial resolution of the lesions.…”

Section: Discussionmentioning

confidence: 99%

“…Furthermore, discontinuation of penicillamine therapy does not guarantee the prevention of further development of the dermatosis. Multiple case reports have described the abrupt onset or recurrence of EPS months to years after stopping penicillamine therapy 9,14,16 . This is likely related to the cumulative dose and the slow clearance of the drug with the remaining effects on the elastic tissue 9 .…”

Section: Discussionmentioning

confidence: 99%

Penicillamine-induced Elastosis Perforans Serpiginosa and Cutis Laxa in a Patient with Wilson's Disease

Choi

Kim

et al. 2010

Ann Dermatol

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Elastosis perforans serpiginosa (EPS) is a rare reactive perforating dermatosis that is characterized by the transepidermal elimination of abnormal elastic fibers. Penicillamine, which is one of the clear triggers for EPS, is a heavy metal chelator that is primarily used for disorders such as cystinuria and Wilson's disease. It may cause alterations in the dermal elastic tissue such as pseudo-pseudoxanthoma elasticum, acquired cutis laxa, EPS and anetoderma. Herein we present a case of cutis laxa and EPS in a 34-year-old man who was previously on a long-term, high-dose of penicillamine for Wilson's disease. The combination of EPS and cutis laxa induced by penicillamine has rarely been reported and we report the first such case in Korea. (Ann Dermatol 22(4) 468 ∼471, 2010)

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“…1 Outland et al described remission of the condition following treatment with 0.1% tazarotene gel. 6 Kelly et al reported success after 10 weeks of therapy with imiquimod. 4 Treatment using CO 2 , Er:YAG and pulsed dye lasers has also been reported in the literature, although results are controversial.…”

Section: An Brasmentioning

confidence: 99%

“…3 There is no standard therapy; however, successful treatment has been reported with the use of cryotherapy with liquid nitrogen, isotretinoin, tazarotene, imiquimod and CO 2 , Er:YAG and pulsed dye lasers. [4][5][6] In a minority of cases, spontaneous resolution of lesions has been reported. 1 report describes the case of a patient with Down's syndrome who has had EPS for the past five years.…”

Section: Introductionmentioning

confidence: 99%

Elastose perfurante serpiginosa em portadora da síndrome de Down

Pereira

Baeta

Júnior

et al. 2010

An. Bras. Dermatol.

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Elastosis perforans serpiginosa is a rare, primary perforating dermatosis, frequently associated with certain genetic diseases and characterized by the transepidermal extrusion of elastic fibers. The present case report describes this dermatosis in a 19-year old female patient with Down's syndrome, who presented with asymptomatic erythematous, keratotic papules in an arciform pattern, located on her right forearm and knee, which had been present for five years. Following histopathological confirmation, treatment with cryotherapy was initiated, resulting in partial remission of the lesions. Keywords: Conjunctive tissue; Down's syndrome; Elastic tissue; Elastic tissue abnormalities Resumo: A elastose perfurante serpiginosa é dermatose perfurante primária incomum, frequentemente associada a determinadas doenças genéticas e caracterizada por eliminação transepidérmica de fibras elásticas. Relata-se um caso raro dessa dermatose em paciente feminina de 19 anos, portadora da sín-drome de Down, que apresentava pápulas eritematoceratóticas em arranjo arciforme, localizadas no antebraço e joelho direitos, assintomáticas, com cinco anos de evolução. Após confirmação histopatológica, foi iniciado tratamento com crioterapia, ocorrendo remissão parcial das lesões.

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Tazarotene Is an Effective Therapy for Elastosis Perforans Serpiginosa

Cited by 45 publications

References 9 publications

Imiquimod Therapy for Elastosis Perforans Serpiginosa

Imiquimod Therapy for Elastosis Perforans Serpiginosa

Penicillamine-induced Elastosis Perforans Serpiginosa and Cutis Laxa in a Patient with Wilson's Disease

Elastose perfurante serpiginosa em portadora da síndrome de Down

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