Tauroursodeoxycholate (TUDCA), chemical chaperone, enhances function of islets by reducing ER stress

Lee, Yeon Yi; Hong, Shin Hee; Lee, Ye-Jin; Chung, Sung Soo; Jung, Hye Seung; Park, Sang Gyu; Park, Kyong Soo

doi:10.1016/j.bbrc.2010.06.022

Cited by 99 publications

(82 citation statements)

References 31 publications

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“…So far it is known that CCK in supraphysiological doses induces acinar cell damage, activates trypsin, and induces proapoptotic signals and ER stress. On the other hand, in endocrine pancreatic cells TUDCA was a useful tool to reduce ER stress (31). We tested this bile salt derivate with ER chaperone-like characteristics in exocrine acinar cells, thereby reducing ER stress, trypsin activation, and apoptosis (35).…”

Section: Discussionmentioning

confidence: 99%

Tauroursodeoxycholic acid reduces endoplasmic reticulum stress, acinar cell damage, and systemic inflammation in acute pancreatitis

Seyhun¹,

Malo²,

Schäfer

et al. 2011

American Journal of Physiology-Gastrointestinal and Liver Physi

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Section: Discussionmentioning

confidence: 99%

Tauroursodeoxycholic acid reduces endoplasmic reticulum stress, acinar cell damage, and systemic inflammation in acute pancreatitis

Seyhun¹,

Malo²,

Schäfer

et al. 2011

American Journal of Physiology-Gastrointestinal and Liver Physi

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“…S2H), indicating the ability of melphalan to activate the PERK and IRE1a arms of the UPR. Addition of the chemical chaperone, TUDCA, which has been reported to alleviate ER stress (33), resulted in decreased levels of phospho-eIF2a ( Fig. 2I) and a partial protection from melphalan-induced cell death (Fig.…”

Section: Melphalan-induced Apoptosis In Vitro Is Modulated By the Commentioning

confidence: 97%

Antitumor Immunity Triggered by Melphalan Is Potentiated by Melanoma Cell Surface–Associated Calreticulin

et al. 2015

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Systemic chemotherapy generally has been considered immunosuppressive, but it has become evident that certain chemotherapeutic drugs elicit immunogenic danger signals in dying cancer cells that can incite protective antitumor immunity. In this study, we investigated whether locoregionally applied therapies, such as melphalan, used in limb perfusion for melanoma (Mel-ILP) produce related immunogenic effects. In human melanoma biopsies, Mel-ILP treatment upregulated IL1B, IL8, and IL6 associated with their release in patients' locoregional sera. Although induction of apoptosis in melanoma cells by melphalan in vitro did not elicit threshold levels of endoplasmic reticulum and reactive oxygen species stress associated with danger signals, such as induction of cell-surface calreticulin, prophylactic immunization and T-cell depletion experiments showed that melphalan administration in vivo could stimulate a CD8 þ T cell-dependent protective antitumor response. Interestingly, the vaccination effect was potentiated in combination with exogenous calreticulin, but not tumor necrosis factor, a cytokine often combined with Mel-ILP. Our results illustrate how melphalan triggers inflammatory cell death that can be leveraged by immunomodulators such as the danger signal calreticulin. Cancer Res; 75(8);

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“…TUDCA is an endogenous bile acid derivative that is likely to increase the stability of unfolded proteins upon the activation of the adaptive UPR. 46 ER stress is reported to be associated with the upregulation of multiple signaling pathways. In this study, ER stress induced the activation of Smad2/3 in HPMCs, and siRNA Figure 8 Effect of TUDCA on TGF-β1-induced EMT and apoptosis.…”

Section: Discussionmentioning

confidence: 99%

Endoplasmic reticulum stress as a novel target to ameliorate epithelial-to-mesenchymal transition and apoptosis of human peritoneal mesothelial cells

Shin

Ryu

et al. 2015

Laboratory Investigation

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Tauroursodeoxycholate (TUDCA), chemical chaperone, enhances function of islets by reducing ER stress

Cited by 99 publications

References 31 publications

Tauroursodeoxycholic acid reduces endoplasmic reticulum stress, acinar cell damage, and systemic inflammation in acute pancreatitis

Tauroursodeoxycholic acid reduces endoplasmic reticulum stress, acinar cell damage, and systemic inflammation in acute pancreatitis

Antitumor Immunity Triggered by Melphalan Is Potentiated by Melanoma Cell Surface–Associated Calreticulin

Endoplasmic reticulum stress as a novel target to ameliorate epithelial-to-mesenchymal transition and apoptosis of human peritoneal mesothelial cells

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