Taurine supplementation induces long-term beneficial effects on glucose homeostasis in ob/ob mice

Borck, Patrícia Cristine; Vettorazzi, Jean Franciesco; Branco, Renato Chaves Souto; Batista, Thiago M.; Santos-Silva, Junia Carolina; Nakanishi, Vanessa Yumi; Boschero, Antônio Carlos; Ribeiro, Rosane Aparecida; Carneiro, Everardo M.

doi:10.1007/s00726-018-2553-3

Cited by 28 publications

(27 citation statements)

References 36 publications

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“…Other studies showed that taurine protected islets and hepatocytes against lipotoxicity induced by the infusion of oleate or fatty acids [29,30]. Borck et al [31] noticed that 5% taurine solution given to obese mice with drinking water for 12 months decreased TAG and improved glucose tolerance and insulin sensitivity. In another study conducted by this team, 2.5% TAU solution given to hypothalamic obese rats for a shorter period (130 days) did not affect the fasting glucose level, but decreased the insulin and TAG concentration [32].…”

Section: Discussionmentioning

confidence: 99%

The Influence of Taurine Supplementation on Serum and Tissular Fe, Zn and Cu Levels in Normal and Diet-Induced Insulin-Resistant Rats

Król

Okulicz

Kupsz

2020

Biol Trace Elem Res

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Taurine (Tau) is a β-sulphonated amino acid postulated to improve glucose homeostasis in insulin resistance and diabetes. Changes in carbohydrate metabolism are accompanied by oxidative stress, which may disturb the mineral balance. Therefore, the aim of this study was to assess the effect of Tau supplementation on the levels of trace elements in rats fed either a standard (AIN-93M, 4% fat) diet or a modified high-fat diet (30% fat). For 8 weeks, male Wistar rats were fed these diets supplemented with 3% Tau. Taurine supplementation normalized increased serum insulin concentration and insulin resistance index; however, it did not improve serum CRP concentration in high-fat diet fed rats. The high-fat diet supplemented with Tau decreased the renal and splenic Zn levels, but the tissular Fe content did not change. The effect of Tau supplementation on the mineral balance to some extent depended on the fat content in the rats' diet. The high-fat diet supplemented with Tau decreased the rats' splenic Zn levels but increased their femur levels. In the group fed the standard diet, Tau reduced the rats' femur Zn level, whereas their splenic Zn level was comparable. Tau supplementation decreased the renal Cu level and serum ceruloplasmin concentration in the rats fed the standard diet, but this effect was not observed in the rats fed the high-fat diet. In conclusion, supplementary taurine failed to ameliorate disturbances in mineral homeostasis caused by high-fat diet feeding and led to tissular redistribution of Zn and Cu in the rat.

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Section: Discussionmentioning

confidence: 99%

The Influence of Taurine Supplementation on Serum and Tissular Fe, Zn and Cu Levels in Normal and Diet-Induced Insulin-Resistant Rats

Król

Okulicz

Kupsz

2020

Biol Trace Elem Res

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“…Finally, 12 papers were selected for inclusion in this systematic review. [27][28][29][30][31][32][33][34][35][36][37][38] Currently, two clinical trials are also ongoing which their results have not been yet published. 39,40 A flowchart of the process of studies selection has been summarized in Figure 1.…”

Section: Analysis Of the Datamentioning

confidence: 99%

“…Majority of the animal studies used spontaneous model of T2DM including Otsuka Long-Evans Tokushima fatty (OLETF) rats, 28,30,31,33 GK rats, 29 and ob/ob rats. 34 Two studies induced diabetes by high fat and high sugar diet combined with streptozotocin (STZ) 32 and feeding the genetically hyperglycemic KK mice a high calorie diet. 27 Of the 8 animal articles identified, 7 articles included measures of blood glucose, [27][28][29][30][32][33][34] 4 included measures of insulin, [29][30][31]34 and 6 evaluated lipid profile.…”

Section: Characteristics Of the Included Studiesmentioning

confidence: 99%

A Comprehensive Insight into Potential Roles of Taurine on Metabolic Variables in Type 2 Diabetes: A Systematic Review

et al. 2020

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Background: Prevention and management of type 2 diabetes mellitus (T2DM), as a major, noncommunicable disease with increasing prevalence, is one of the major human challenges. The aim of this systematic review is to summarize current studies about the potential roles of taurine in T2DM, to identify knowledge gaps and to provide recommendations for the way forward. Methods: The literature search was performed in PubMed, SCOPUS, Embase, ProQuest and Google Scholar electronic databases to December 2019. All studies investigating the impacts of taurine in T2DM which met the inclusion criteria were eligible. Results: Out of 1381 articles found in the search, 12 were included. Findings of taurine supplementation on glycemic control in T2DM showed improving effect of taurine on fasting and postprandial blood glucose, serum insulin level, insulin resistance, function of beta cells, and insulin sensitivity. But, the results for Hemoglobin A1c and homeostatic model assessmentinsulin resistance (HOMA-IR) were contradictory. Also, taurine reduced total cholesterol, TG, and low density lipoprotein-cholesterol (LDL-C) levels, however, the evidence on high density lipoprotein-cholesterol (HDL-C) was insufficient. Findings didn not support antioxidative role of taurine in T2DM. Conclusion:As a whole, taurine has potential to improve glycemic status and dyslipidemia. However, more clinical trials are needed to explore precise mechanisms underlying taurine on metabolic variables, oxidative stress, and inflammatory biomarkers, according to the recommendations for future directions.

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“…Taurine, which is present in octopus and shellfish, is a feedstock of bile and enhances the production rate from cholesterol to bile. Therefore, positive and frequent eating of foods containing these compounds decrease triglyceride and LDL cholesterol levels, consequently preventing arteriosclerosis [17,18].…”

Section: Foods That Decrease the Risk Of Lifestyle Diseasesmentioning

confidence: 99%

Introductory Chapter: Design of an Ideal Diet Using Common Foods

Shiomi¹

2018

Current Topics on Superfoods

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Recently, superfoods, instead of dietary supplements or functional foods, are considered an effective mode of intake of active ingredients. The word "superfood" is a marketing term and is not correctly defined. The idea of superfood was first proposed by Platt [3] and Wolfe [4]. According to the concept of Platt, superfood can be defined as a low-calorie food containing active ingredients that decrease the risk of diseases, such as cancer and dementia. Wolfe defined the word "superfood" as a food that contains extremely high concentrations of active ingredients or important nutrients. Foods shown in Table 1 have been selected as typical superfoods based on these concepts, and their characteristics have been previously examined [5, 6].

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Taurine supplementation induces long-term beneficial effects on glucose homeostasis in ob/ob mice

Cited by 28 publications

References 36 publications

The Influence of Taurine Supplementation on Serum and Tissular Fe, Zn and Cu Levels in Normal and Diet-Induced Insulin-Resistant Rats

The Influence of Taurine Supplementation on Serum and Tissular Fe, Zn and Cu Levels in Normal and Diet-Induced Insulin-Resistant Rats

A Comprehensive Insight into Potential Roles of Taurine on Metabolic Variables in Type 2 Diabetes: A Systematic Review

Introductory Chapter: Design of an Ideal Diet Using Common Foods

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