Taurine prevents enhancement of acetylcholinesterase activity induced by acute ethanol exposure and decreases the level of markers of oxidative stress in zebrafish brain

The Effect of Taurine on Hepatic Steatosis Induced by Thioacetamide in Zebrafish (Danio rerio)

“…We have not found any study to date that has analyzed the effect of taurine on oxidative stress in the zebrafish liver. Taurine has been previously evaluated in the zebrafish brain exposed to ethanol and was shown to prevent the increase of lipid peroxidation induced by ethanol [37]. Our finding is consistent with previous studies in rats, which also observed a higher content of malondialdehydes in the TAA-induced hepatic damage group as well as a reduction of hepatic lipoperoxidation when taurine was co-administered with TAA [8,28].…”

Effects of Methoxsalen fromPoncirus trifoliataon Acetylcholinesterase and Trimethyltin-Induced Learning and Memory Impairment

“…The authors discussed that acute ethanol, and induction of oxidative stress might be reasons for AchE activation. 26) Similarly, Kaizer et al investigated to determine whether long-term exposure to aluminum affects AchE activity in different mouse brain regions. 27) Long-term oral administration of aluminum (along with citrate supplementation for better absorption) increased AchE activity in all the investigated brain regions (the cortex, striatum, hippocampus, and hypothalamus), and the authors concluded that alteration of the lipid membrane might be a decisive factor in the modulation of AchE activity.…”

Zebrafish locomotor capacity and brain acetylcholinesterase activity is altered by Aphanizomenon flos-aquae DC-1 aphantoxins

“…AChE activity has been widely used as a bioindicator of environmental exposure and there are a number of studies in the literature concerning the effects of environmental organic pollutants, heavy metals and other chemical toxicants on AChE activity in animals (Rao et al, 2005a,b;Rico et al, 2006Rico et al, , 2007Rosemberg et al, 2010;Richetti et al, 2011;Pereira et al, 2012). However, this is the first study to correlate the effects of aphantoxins on brain AChE activity and the locomotor behavioral activity of exposed animals.…”

“…AChE inhibition may be a compensatory mechanism that attempts to decrease the hydrolysis of free ACh and thereby increase the concentration of this neurotransmitter in the synaptic cleft where it is essential for the generation of nervous impulses (Rosemberg et al, 2010). On the other hand, AChE inhibition, may be related to cell damage in the nervous system because AChE is an enzyme anchored mainly in the cell membrane in brain regions rich in cholinergic pathways (Rodrigues et al, 2009;da Silva et al, 2011a).…”