Taurine inhibits KDM3a production and microglia activation in lipopolysaccharide-treated mice and BV-2 cells

Liu, Kun; Zhu, Runying; Jiang, Hong; Li, Bin; Geng, Qi Rong; Li, Yanning; Qi, Jinsheng

doi:10.1016/j.mcn.2022.103759

Cited by 8 publications

(3 citation statements)

References 36 publications

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“…Finally, in a recent work, taurine was administered to lipopolysaccharide (LPS)-treated mice and microglial (BV-2) cells. Taurine inhibited the LPS-induced increase in lysine demethylase 3a (KDM3a), a promoter of inflammation and microglia activation, improved the sociability of LPS-treated mice, inhibited microglia activation in the hippocampus, and reduced generation of brain inflammatory factors, such as interleukin-6, tumor necrosis factor-α, inducible nitric oxide synthase, and cyclooxygenase-2 [118].…”

Section: Discussionmentioning

confidence: 99%

On the Potential Therapeutic Roles of Taurine in Autism Spectrum Disorder

2022

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Contemporary research has found that people with autism spectrum disorder (ASD) exhibit aberrant immunological function, with a shift toward increased cytokine production and unusual cell function. Microglia and astroglia were found to be significantly activated in immuno-cytochemical studies, and cytokine analysis revealed that the macrophage chemoattractant protein-1 (MCP-1), interleukin 6 (IL-6), tumor necrosis factor α (TNF-α), and transforming growth factor β-1 (TGFB-1), all generated in the neuroglia, constituted the most predominant cytokines in the brain. Taurine (2-aminoethanesulfonic acid) is a promising therapeutic molecule able to increase the activity of antioxidant enzymes and ATPase, which may be protective against aluminum-induced neurotoxicity. It can also stimulate neurogenesis, synaptogenesis, and reprogramming of proinflammatory M1 macrophage polarization by decreasing mitophagy (mitochondrial autophagy) and raising the expression of the markers of the anti-inflammatory and pro-healing M2 macrophages, such as macrophage mannose receptor (MMR, CD206) and interleukin 10 (IL-10), while lowering the expression of the M1 inflammatory factor genes. Taurine also induces autophagy, which is a mechanism that is impaired in microglia cells and is critically associated with the pathophysiology of ASD. We hypothesize here that taurine could reprogram the metabolism of M1 macrophages that are overstimulated in the nervous system of people suffering from ASD, thereby decreasing the neuroinflammatory process characterized by autophagy impairment (due to excessive microglia activation), neuronal death, and improving cognitive functions. Therefore, we suggest that taurine can serve as an important lead for the development of novel drugs for ASD treatment.

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Section: Discussionmentioning

confidence: 99%

On the Potential Therapeutic Roles of Taurine in Autism Spectrum Disorder

2022

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“…Taurine has been thought to be essential for the development and survival of neural cells and to protect them under cell-damaging conditions, indeed in the brain stem taurine regulates vital functions, including cardiovascular control and arterial blood pressure. Its neuroprotective effects involve also reducing neuronal apoptosis and inflammation [46], making it a subject of interest in research on neurodegenerative diseases and brain injuries and offering benefits during stroke recovery [52][53][54][55][56]. Premature infants are vulnerable to taurine deficiency because they lack some of the enzymes needed to synthesize cysteine and taurine.…”

Section: Tissuementioning

confidence: 99%

Functional Role of Taurine in Aging and Cardiovascular Health: An Updated Overview

Santulli,

Kansakar,

Varzideh

et al. 2023

Nutrients

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Taurine, a naturally occurring sulfur-containing amino acid, has attracted significant attention in recent years due to its potential health benefits. Found in various foods and often used in energy drinks and supplements, taurine has been studied extensively to understand its impact on human physiology. Determining its exact functional roles represents a complex and multifaceted topic. We provide an overview of the scientific literature and present an analysis of the effects of taurine on various aspects of human health, focusing on aging and cardiovascular pathophysiology, but also including athletic performance, metabolic regulation, and neurological function. Additionally, our report summarizes the current recommendations for taurine intake and addresses potential safety concerns. Evidence from both human and animal studies indicates that taurine may have beneficial cardiovascular effects, including blood pressure regulation, improved cardiac fitness, and enhanced vascular health. Its mechanisms of action and antioxidant properties make it also an intriguing candidate for potential anti-aging strategies.

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“…Meanwhile, transforming growth factor-β (TGF-β1), a cell transformation factor, regulated cellular immune function, fibrosis, and cancer progression [ 17 ]. Remarkably, both KDM3A and TGF-β1 had protective roles under hypoxic organ conditions and contributed to responses to neuroinflammation [ 18 , 19 , 20 , 21 ]. Our research findings lead us to propose that circadian rhythm disruption might exacerbate AD development via the methylation of key gene m 6 A, which might be related to KDM3A and TGF-β1.…”

Section: Introductionmentioning

confidence: 99%

Hif3α Plays Key Roles in the Progression of Alzheimer’s Disease Caused by Circadian Rhythm Disruption through Regulating the m6A/KDM3A/TGF-β1 Axis

Li,

Han,

2024

Biology

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Disrupted circadian rhythms are associated with the onset of chronic diseases and impairments, including cancer, diabetes, and hypertension. However, whether circadian disruptions accelerate the progression of Alzheimer’s disease and the respective pathway remains unclear. In this study, we constructed animal models using male C57BL/6N and APP/PS1 mice. Irregular illumination during sleeping hours was administered to the mice in our intervention groups to consistently disrupt their circadian rhythms. The impact of the intervention was evaluated through body weight tracking, cerebral index determination, histopathological staining, and biochemical marker analysis. Transcriptomic sequencing identified critical genes, with the data subsequently validated using RNA m6A detection and site analysis. The evaluations revealed that circadian disruptions impaired normal weight gain, liver and kidney functions, neuronal cells, and overall brain function. Transcriptomic sequencing data revealed a trend of elevating expression of Hif3α mRNA in the intervention groups. Further analysis of specific gene sites revealed that m6A methylation of the Hif3α gene at m6A site 3632 primarily drove the observed variations in HIF3A protein expression in our model. Furthermore, the expression of proteins in PC12 cells, N2a cells, and mice brains validated that an increase in HIF3A expression decreased KDM3A and TGF-β1 protein expression. Our study reveals a hitherto unknown pathway through which the disruption of circadian rhythms, by triggering m6A methylation at m6A site 3632 in the Hif3α gene, leads to the initiation and acceleration of AD. These findings provide valuable insights and guidelines for treating AD patients and enhancing caregiving by professionals.

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Taurine inhibits KDM3a production and microglia activation in lipopolysaccharide-treated mice and BV-2 cells

Cited by 8 publications

References 36 publications

On the Potential Therapeutic Roles of Taurine in Autism Spectrum Disorder

On the Potential Therapeutic Roles of Taurine in Autism Spectrum Disorder

Functional Role of Taurine in Aging and Cardiovascular Health: An Updated Overview

Hif3α Plays Key Roles in the Progression of Alzheimer’s Disease Caused by Circadian Rhythm Disruption through Regulating the m6A/KDM3A/TGF-β1 Axis

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