Taurine in nutrition and brain development

Chapman, Gwenneth E.; Greenwood, Carol E.

doi:10.1016/s0271-5317(88)80135-0

Cited by 21 publications

(9 citation statements)

References 63 publications

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“…Also, taurine plays an important role in fetal development because taurine deficiency during pregnancy is associated with growth retardation, retinal degeneration and dysfunction of the central nervous system (CNS) [5,6]. In general, it was known that taurine can be supplied to most of human tissues by diet or biosynthesis in human body.…”

Section: Introductionmentioning

confidence: 99%

Regulation of taurine transport at the blood-placental barrier by calcium ion, PKC activator and oxidative stress conditions

Lee

Kang

2010

J Biomed Sci

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BackgroundIn the present study, we investigated the changes of uptake and efflux transport of taurine under various stress conditions using rat conditionally immortalized syncytiotrophoblast cell line (TR-TBT cells), as in vitro blood-placental barrier (BPB) model.MethodsThe transport of taurine in TR-TBT cells were characterized by cellular uptake study using radiolabeled taurine. The efflux of taurine was measured from the amount of radiolabeled taurine remaining in the cells after the uptake of radiolabeled taurine for 60 min.ResultsTaurine uptake was significantly decreased by phosphorylation of protein kinase C (PKC) activator in TR-TBT cells. Also, calcium ion (Ca2+) was involved in taurine transport in TR-TBT cells. Taurine uptake was inhibited and efflux was enhanced under calcium free conditions in the cells. In addition, oxidative stress induced the change of taurine transport in TR-TBT cells, but the changes were different depending on the types of oxidative stress inducing agents. Tumor necrosis factor-α (TNF-α), lipopolysaccharide (LPS) and diethyl maleate (DEM) significantly increased taurine uptake, but H2O2 and nitric oxide (NO) donor decreased taurine uptake in the cells. Taurine efflux was down-regulated by TNF-α in TR-TBT cells.ConclusionTaurine transport in TR-TBT cells were regulated diversely at extracellular Ca2+ level, PKC activator and oxidative stress conditions. It suggested that variable stresses affected the taurine supplies from maternal blood to fetus and taurine level of fetus.

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Section: Introductionmentioning

confidence: 99%

Regulation of taurine transport at the blood-placental barrier by calcium ion, PKC activator and oxidative stress conditions

Lee

Kang

2010

J Biomed Sci

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“…The necessity of this supplementation remains disputed as clinical studies have not provided evidence of any clinical effects of growth and development in preterm or low birth weight infants [56]. High concentrations of taurine in the developing brain [57], as well as results from various animal studies clearly indicate the importance of taurine in neurodevelopment [58,59].…”

Section: Taurine Supplementationmentioning

confidence: 99%

Anticholesterolemic and Antiatherogenic Effects of Taurine Supplementation is Model Dependent

Eilertsen¹,

Larsen²,

Mæhre³

et al. 2012

Lipoproteins - Role in Health and Diseases

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“…Wolffram et al [48] concluded that diffusive uptake of taurine may be sufficient to meet requirements in the cat in view of its carnivorous diet, which is concentrated in taurine in comparison with a herbivorous diet [66]. However, the cat is particularly vulnerable to taurine depletion, which results in severe retinal degeneration, myocardial infarction and reproductive disturbances [67][68][69]. It is, therefore, plausible that the absence of an active transport system for taurine in the cat intestine would contribute to its vulnerability to taurine depletion.…”

Section: Differences In Taurine Transport Between Speciesmentioning

confidence: 99%

Intestinal taurine transport: a review

O'Flaherty

Stapleton

Redmond

et al. 1997

Eur J Clin Investigation

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Abstract. Intestinal uptake of dietary taurine is an important contributor to taurine homeostasis and may become crucial when taurine metabolism is impaired. This review aims to assess the literature documenting taurine transport and review what is currently known about the operation of the enterocyte taurine transport protein. Sources included MedLine searches from the last 10 years and references from original and review articles. The aim was to include human and animal studies directly addressing the subject of taurine uptake by enterocytes. Intestinal taurine transport has been well documented in in vivo studies using many different animal models. The mechanistic/kinetic aspects of the transport system have been extensively documented. However, little is known about what regulates the system. The recent development of a cell culture model of intestinal taurine transport will allow studies to explore the regulation of gut taurine uptake, which promises to be a very exciting area.

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Taurine in nutrition and brain development

Cited by 21 publications

References 63 publications

Regulation of taurine transport at the blood-placental barrier by calcium ion, PKC activator and oxidative stress conditions

Regulation of taurine transport at the blood-placental barrier by calcium ion, PKC activator and oxidative stress conditions

Anticholesterolemic and Antiatherogenic Effects of Taurine Supplementation is Model Dependent

Intestinal taurine transport: a review

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