Taurine improves graft survival after experimental liver transplantation

Schemmer, Peter; Liang, Rui; Kinčius, Marius; Flechtenmacher, Christa; Bunzendahl, H.; Gutt, Carsten N.; Mehrabi, Arianeb; Gebhard, Martha Maria; Büchler, Markus W.; Kraus, Thomas

doi:10.1002/lt.20501

Cited by 27 publications

(32 citation statements)

References 41 publications

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“…Most recently, taurine has been clearly demonstrated to improve graft survival after cold ischemia and subsequent liver transplantation in an animal model [11] , and to protect hearts from myocardial infarction [21] ; however, its effects on liver after warm ischemia with subsequent reperfusion remain unknown. Thus, this study was designed to demonstrate its effects on liver after warm ischemia/reperfusion.…”

Section: Discussionmentioning

confidence: 99%

“…Further, taurine has been shown to hyperpolarize the KC membrane in vitro via mechanisms involving cellular chloride ion influx, which in turn blunts the lipopolysaccharide-induced increase of [Ca 2+ ] i and the subsequent TNF-␣ production [10] . Most recently, donor preconditioning with taurine has been shown to increase graft survival after experimental cold ischemia with subsequent liver transplantation [11] . Thus, this study has been designed to investigate effects of taurine on pathologic changes to the liver after warm ischemia.…”

Section: Introductionmentioning

confidence: 99%

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Taurine Protects from Liver Injury after Warm Ischemia in Rats: The Role of Kupffer Cells

et al. 2007

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Background/Aims: Warm ischemia to liver with subsequent Kupffer cell-dependent pathology is associated with many clinical conditions. Taurine prevents Kupffer cell activation and improves graft survival after experimental cold ischemia and liver transplantation. Thus this study was designed to assess its effects after warm hepatic ischemia. Methods: The left liver lobe of female Sprague-Dawley rats (170–210 g) underwent 60 min of warm ischemia. Animals were given either intravenous taurine or Ringer’s solution 10 min prior to warm ischemia. Transaminases, histology, in vivo microscopy, intercellular adhesion molecules-1 (ICAM-1) expression, TNF-α and tissue hydroperoxide were compared between groups using analysis of variance (ANOVA) or ANOVA on ranks as appropriate. Results: Taurine significantly decreased transaminases and improved histologic outcome. Phagocytosis of latex beads, serum TNF-α levels and tissue hydroperoxide concentrations were also significantly reduced. Stickers in sinusoids and post-sinusoidal venules significantly decreased. In parallel, both leukocyte infiltration and ICAM-1 expression decreased (p < 0.05), while flow velocity of red blood cells as well as sinusoidal perfusion rate were improved (p < 0.05). Conclusion: This study demonstrates that taurine blunts Kupffer cell-dependent hepatic pathology after warm ischemia in vivo via mechanisms including leukocyte-endothelial interaction, microcirculation disturbances and protection against lipid peroxidation.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Taurine Protects from Liver Injury after Warm Ischemia in Rats: The Role of Kupffer Cells

et al. 2007

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“…F-7250; Sigma, Germany) were injected i.v. 30 min prior to IVM (1.0 ml/ kg BW FITC-labelled erythrocytes) [26] .…”

Section: Histological Assessmentmentioning

confidence: 99%

“…The upper surface of the left liver lobe was exteriorized on a specially designed mechanical stage [26] . Hepatic microcirculation was observed using an intravital microscope for epi-illumination (Orthoplan; Leica, Wetzlar, Germany; lens with 40-fold magnification, Archoplan 40/0.75 W; Zeiss, Jena, Germany).…”

Section: Histological Assessmentmentioning

confidence: 99%

Alcohol Pretreatment Increases Hepatic and Pulmonary Injury in Experimental Pancreatitis

et al. 2009

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“…It was postulated that taurine has cytoprotective effects on hepatocytes under hyperoxic or hypoxic condition in the presence of Ca 2+ [84,85], protects liver against the hepatotoxic effect of CCl 4 [16,78,79] and monosodium glutamate [16,80,86] that induced hepatocyte necrosis. Moreover, it was postulated that taurine can prevent the acute and chronic damage induced by oxidative agent by decreasing oxidative stress [87].…”

Section: Possible Ameliorative Effect Of Antioxidant (Taurine)mentioning

confidence: 99%

Possible Ameliorative Effect of Antioxidant (Taurine) in Pregnant Toxemic Female Rats

El-Agousa¹,

El-Nashar²,

Eissa³

et al. 2009

TOHYPERJ

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The present study was designed to investigate the possible effects of the antioxidant taurine on pregnant adriamycin (ADR) induced toxemic female rats. ADR was injected intraperitoneally to 50 pregnant female rats (5 groups) to induce toxemia. the first is Frank control group injected only with saline; the second group is the Taurine group that determined the effect of taurine alone; the third group is the Toxemic group that showed the toxicity of Adriamycin; the fourth group is the Therapeutic group (Adriamycin followed by Taurine) and the fifth group is the Protective group (Taurine followed by Adriamycin) that showed the amelurative effect of taurine in these groups.Blood pressure, liver and kidney function, lipid profile, taurine concentration in plasma, serum cortisone, T3 &T4 were measured for all animals. Furthermore, histopathological examination and morphometric study for liver, kidney and cardiac muscle were done for all groups.The results showed that, the Protective group has marked improvement in most biochemical parameters than the Therapeutic group compared to Toxemic group.Morphometric study revealed a significant decrease in the nuclear area in the tissues of toxemic rats. Also, marked disturbances were observed in the histopathological architecture of the kidney, liver and heart in all toxemic rats. However, a marked improvement in morphometrical parameters and histopathological architecture was observed in protective group. The results support the ameliorative effect of taurine in the protection against toxemia during pregnancy in experimental animals.

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Taurine improves graft survival after experimental liver transplantation

Cited by 27 publications

References 41 publications

Taurine Protects from Liver Injury after Warm Ischemia in Rats: The Role of Kupffer Cells

Taurine Protects from Liver Injury after Warm Ischemia in Rats: The Role of Kupffer Cells

Alcohol Pretreatment Increases Hepatic and Pulmonary Injury in Experimental Pancreatitis

Possible Ameliorative Effect of Antioxidant (Taurine) in Pregnant Toxemic Female Rats

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