Taurine Improves Angiotensin II-Induced Hypertrophy of Cultured Neonatal Rat Heart Cells

The Anti-Inflammatory Effect of Taurine on Cardiovascular Disease

“…Interestingly, AngII-incubation followed by short-term taurine (24 h) administration in neonatal rat myocyte decreased [Ca 2+ ]i [53]. However, vice-versa incubations had no effect on the AngII-induced increase in [Ca + ]i [53]. As such, it is not clear whether taurine directly inhibits AngII via AT1R, blocks the conversion of AngI into AngII, or simply influences the signaling cascade of AngII in cardiac hypertrophy.…”

“…Taurine has also been reported to directly inhibit the actions of AngII in neonatal rat myocyte, and prevent AngII-induced cell proliferation and gene expression (e.g., cellular-fos (oncogene) and cellular-jun(proto-oncogene) genes) in cultured cardiac fibroblasts [51][52][53]. As AngII could trigger the Na + /Ca 2+ exchanger, leading to an influx of intracellular calcium ion ([Ca 2+ ]i), it is possible that taurine may regulate this ion exchanger in cardiac myocytes and inhibit AngII effects on cardiac hypertrophy [53]. Interestingly, AngII-incubation followed by short-term taurine (24 h) administration in neonatal rat myocyte decreased [Ca 2+ ]i [53].…”

“…As AngII could trigger the Na + /Ca 2+ exchanger, leading to an influx of intracellular calcium ion ([Ca 2+ ]i), it is possible that taurine may regulate this ion exchanger in cardiac myocytes and inhibit AngII effects on cardiac hypertrophy [53]. Interestingly, AngII-incubation followed by short-term taurine (24 h) administration in neonatal rat myocyte decreased [Ca 2+ ]i [53]. However, vice-versa incubations had no effect on the AngII-induced increase in [Ca + ]i [53].…”

L-Arginine Fails to Prevent Ventricular Remodeling and Heart Failure in the Spontaneously Hypertensive Rat

“…Taurine administration has also been reported to protect against cerebrovascular damage in stroke-prone hypertensive rats in vivo 11 and to reduce angiotensin II-induced cardiac hypertrophy in vitro. 26 Therefore, taurine might be expected to reduce cardiac hypertrophy and myocardial remodeling. 27 The findings from this study, however, suggest that the antioxidant effects of taurine does not appear to afford protection against the development of HF in the SHR, and are consistent with the well-recognized concept that angiotensin II rather than oxidant action is, in large part, responsible for the progression of cardiac hypertrophy and the development of HF in the SHR.…”

Mechanisms of action of compounds that mimic beneficial effects of calorie restriction such as lifespan extension: Is taurine a promising candidate?

“…Interestingly, several studies have reported that taurine increases plasma adiponectin levels 34) . Moreover, it has been reported that taurine inhibits angiotensin II 38) , suggesting that taurine may have a similar effect as that of the ARBs.…”