Taurine (2-Aminoethanesulfonic Acid) Deficiency Creates a Vicious Circle Promoting Obesity

Abstract

The relation between blood taurine (2-aminoethanesulfonic acid) concentrations and obesity was investigated. Taurine is supplied to the body by dietary ingestion as well as by de novo synthesis; it is anabolized by cysteine dioxygenase (CDO), which is abundantly expressed in liver and white adipose tissue. Overexpression of CDO in 3T3-L1 preadipocytes caused a decrease in the level of cysteine (precursor of taurine) and an increase in the level of taurine in the culture medium, suggesting that CDO is involved in biosynthesis and secretion of taurine in white adipose tissue. In high-fat diet-induced and/or genetically obese mice, a decrease in the blood taurine concentration was observed along with a decrease in CDO expression in adipose tissue but not in liver. Dietary taurine supplementation prevented high-fat diet-induced obesity with increased resting energy expenditure. Thus, taurine deficiency observed in association with obesity may create a vicious circle promoting obesity. Dietary taurine supplementation interrupts this vicious circle and may prevent obesity.

Randomized trial of weight-loss-diets for young adults varying in fish and fish oil content

“…29 Additionally, a recent study found dietary taurine supplementation to prevent obesity in mice by increased resting energy expenditure. 30 Further studies are needed to examine possible mechanisms. In addition, closer investigation of the effects of portion size and more frequent fish consumption as part of a varied and balanced diet is required.…”

The Relationship between Plasma Levels of Large Neutral Amino Acids and Leptin in Women with or Without Obesity

“…Ornithine, an intermediate of urea cycle, was elevated in obese women suggesting that they might have abnormal hepatic urea synthesis [11,18]. Taurine supplementation to obese subjects can effectively increase fatty acid oxidation [20]. Furthermore, high-fat obese rodents have high hepatic taurine content with accompanying hypotaurinemia [18,20].…”

“…Taurine supplementation to obese subjects can effectively increase fatty acid oxidation [20]. Furthermore, high-fat obese rodents have high hepatic taurine content with accompanying hypotaurinemia [18,20]. Thus, elevated hepatic taurine is a compensatory mechanism to overcome high-fat supply.…”

Cognitive Impairment Treatment in Arterial Hypertension With Diabetes Mellitus 2nd Type

“…Заболеваемость СД и АГ увеличи-вается с возрастом среди жителей экономически раз-витых стран. У большинства больных СД 2 типа, составляющих около 90% лиц с СД и АГ, отмечается эссенциальная гипертензия [4,5].…”