Taste receptor type 1 member 3 enables western diet-induced anxiety in mice
Jae Won Song,
Keon-Hee Lee,
Hobin Seong
et al.
Abstract:Background
Accumulating evidence supports that the Western diet (WD), a diet high in saturated fat and sugary drinks, contributes to the pathogenesis of anxiety disorders, which are the most prevalent mental disorders worldwide. However, the underlying mechanisms by which WD causes anxiety remain unclear. Abundant expression of taste receptor type 1 member 3 (TAS1R3) has been identified in the hypothalamus, a key brain area involved in sensing peripheral nutritional signals and regulating anxie… Show more
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