Taste masking of ondansetron hydrochloride by polymer carrier system and formulation of rapid-disintegrating tablets

Khan, Shagufta; Kataria, Prashant; Nakhat, Premchand; Yeole, Pramod

doi:10.1208/pt0802046

Cited by 113 publications

(84 citation statements)

References 18 publications

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“…The diffractograms of bromocriptine mesylate as a pure drug and the selected formula were obtained. The study was confirmed by using Shimadzu XRD-6000 powder X-ray diffractometer at continuous scan range of 5 °-80 ° of 2Ɵ The operating voltage was 40 (kV) and current 30mA [24].…”

Section: X-ray Powder Diffraction (Xrpd)mentioning

confidence: 99%

Formulation and in Vitro Evaluation of Bromocriptine Mesylate as Fast Dissolving Oral Film

2018

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Objective: The aim of this study was to formulate and in vitro evaluate fast dissolving oral film of practically insoluble bromocriptine mesylate to enhance its solubility and to improve its oral bioavailability by avoiding first pass effect as well as to produce an immediate release action of the drug from the film for an efficient management of diabetes mellitus type II in addition to an improvement of the patient compliance to this patientfriendly dosage form. Methods:The films were prepared by the solvent casting method using hydroxypropyl methylcellulose of grades (E3, E5, E15), polyvinyl alcohol (PVA), pectin and gelatin as film-forming polymers in addition to polyethene glycol 400 (PEG400), propylene glycol (PG) and glycerin were used as a plasticizer. Poloxamer 407 was used as a surfactant, sodium saccharin as a sweetening agent, citric acid as a saliva stimulating agent, vanilla as a flavouring agent and crospovidone as a super disintegrant. The prepared films then tested for physical characterization, thickness, weight uniformity, mechanical characteristics (folding endurance, tensile strength, percent elongation and Young's modulus), surface pH, in vitro disintegration time, drug content and an in vitro drug release.Results: Films were found to be satisfactory when evaluated for physical characterization, thickness, weight uniformity, mechanical tests, in vitro disintegration time, folding endurance, drug content and an in vitro drug release. The surface pH of all the films was found to be neutral or minor change. Films in vitro drug release studies were also done using USP dissolution apparatus type II (paddle type). The in vitro drug release profile in the optimized formulation F14 was gave 86.8 % of drug released at 2 min. The optimized formulation F14 was also showed satisfactory pH (6.2±0.2), drug content (99.2±0.5%), the disintegration time of 9.2±0.1 seconds and the time needed for 80% of medication to be released (T80 %) was 1.35 minute. Conclusion:The bromocriptine mesylate fast dissolving oral film was formulated. The given film disintegrates within nine seconds which release the drug rapidly and gives an action.

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Section: X-ray Powder Diffraction (Xrpd)mentioning

confidence: 99%

Formulation and in Vitro Evaluation of Bromocriptine Mesylate as Fast Dissolving Oral Film

2018

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“…The optimized ratio of 1:3 CTZ:hydroxypropyl β-CD was appropriate for taste masking [9,10] . CTZ was coated by a fluidized bed coating using Eudragit ® RL30-D and taste-masking evaluation was performed by healthy human volunteers and their perceived levels were recorded on a numerical scale [11,12] . Moreover, rizatriptan benzoate and β-CD prepared by kneading with distilled water demonstrated effective taste masking [13] .…”

Section: Research Papermentioning

confidence: 99%

Cetirizine Dihydrochloride, beta-Cyclodextrin Inclusion Complex by Ethanol Kneading for Taste Masking

Katewongsa¹,

Lertsuphotvanit²,

Phaechamud³

2017

pharmaceutical-sciences

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Katewongsa, et al.: Cetirizine Dihydrochloride and β-Cyclodextrin Complex by Ethanol KneadingCetirizine dihydrochloride has a very unpleasant bitter taste. To mask the bitter taste, complexation with β-cyclodextrin using ethanol as a kneading solvent was investigated and evaluated by Fourier transform infrared spectroscopy, differential scanning calorimetry, powder X-ray diffractometry, thermogravimetric analysis, simultaneous X-ray diffractometry-differential scanning calorimetry measurement and 1 H-nuclear magnetic resonance spectroscopy. Taste was evaluated by human volunteers using an unstructured line scale. The basic characterization of the prepared tablets including in vivo disintegration time and drug dissolution was studied. Fourier transform infrared spectroscopy, differential scanning calorimetry and powder X-ray diffractometry data confirmed the inclusion complex formation. Thermogravimetric analysis, simultaneous X-ray diffractometry-differential scanning calorimetry measurements revealed the reduction of crystalline β-cyclodextrin due to the displacement of water molecules from complex formation. Proton nuclear magnetic resonance spectroscopy indicated an intermolecular interaction between protons of cetirizine dihydrochloride with the cavity of β-cyclodextrin. The prepared complex showed an unstructured line scale with apparent low average rating of 1.70. The inclusion complex-loaded fast disintegrating tablet prepared with direct compression had short disintegration time and good taste with an unstructured line scale with average rating of 0.28. Cetirizine dihydrochloride, β-cyclodextrin inclusion complex was successfully prepared by kneading method using ethanol as solvent. The inclusion complex-loaded fast disintegrating tablet had good taste and good perception in the mouth.

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“…In vitro disintegration study [19][20][21] The in vitro disintegration test for prepared tablets was carried out using USP disintegration test apparatus. Six tablets were placed individually in each tube of disintegration test apparatus, and discs were placed over each tablet.…”

Section: Content Uniformity Test [18]mentioning

confidence: 99%

Enhancement of the Dissolution Rate of Nateglinide Tablets Using Liquisolid Compact Technique

Mamatha¹,

Sultana²

2017

Asian J Pharm Clin Res

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Objective: The main objective of this work is to develop new formulation to enhance the solubility of a highly permeable and a poorly soluble oral drug antihyperglycemic agent, nateglinide by liquisolid compacts. Methods:The liquisolid compact technique is based on dissolving the insoluble drug in propylene glycol, polyethylene glycol 400, tween-80 as non-volatile solvents in which drug is having high solubility and admixture of drug loaded solution with microcrystalline cellulose as carrier, aerosil as coating material, crospovidone as disintegrant, and magnesium stearate as lubricant to convert into acceptably flowing and compressible powder. The prepared liquisolid compacts were evaluated for their flowing properties such as bulk density, tapped density, angle of repose, Hausner's ratio, and Carr's index. Further tablets were evaluated for hardness, thickness, weight variation, friability, disintegration test, and in vitro release study. Result:Higher drug release profiles due to increased wetting property and surface area of the drug available for dissolution was obtained in case of liquisolid compacts. Among all formulations, liquisolid system prepared by propylene glycol was considered as best formulation which release drug up to 98% in 60 minutes and in comparison to marketed formulation, optimized formulation showed better dissolution profile. Conclusion:It can be concluded that liquisolid compact technique could be a promising strategy in improving the dissolution of poor water soluble drugs.

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Taste masking of ondansetron hydrochloride by polymer carrier system and formulation of rapid-disintegrating tablets

Cited by 113 publications

References 18 publications

Formulation and in Vitro Evaluation of Bromocriptine Mesylate as Fast Dissolving Oral Film

Formulation and in Vitro Evaluation of Bromocriptine Mesylate as Fast Dissolving Oral Film

Cetirizine Dihydrochloride, beta-Cyclodextrin Inclusion Complex by Ethanol Kneading for Taste Masking

Enhancement of the Dissolution Rate of Nateglinide Tablets Using Liquisolid Compact Technique

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