Targetoid Hemosiderotic Hemangioma Occurring in a Father and Son

Hobnail haemangioma associated with the menstrual cycle

“…A familial occurrence of HH has also been reported in a father and his son, 10 although this is an isolated report and the association could have been casual.…”

“…2,9 Chronic inflammation due to some persistent antigen could promote vascular permeability and leakage of red blood cells. 2 A familial occurrence of HH has also been reported in a father and his son, 10 although this is an isolated report and the association could have been casual.…”

Clinicopathologic challenge

“…Other studies have suggested a lymphatic origin for these lesions, supported by the general lack of CD34 staining and limited actin‐positive pericytes 5,6 . Cyclical variation in palpability, size, and hue of these lesions has been reported on several occasions 4,7,8 . One study reported an association with pregnancy or the menstrual cycle, with vasoreactivity secondary to estrogen and progesterone as a proposed mechanism 8 …”

Superficial Hemosiderotic Lymphovascular Malformation (Hobnail Hemangioma): A Report of Six Cases

“…It is possible that our patients and perhaps some of those reported in the literature without a peripheral halo characteristic of a THH (2,3) had a surrounding ring that resolved before the time of examination, although it is also possible that the lesions of our patients underwent color changes without the presence of a peripheral halo. Cyclic morphologic changes of SHLM including color changes have been reported in children (11) and adults (8,15). Because of the small size and benign nature of SHLM/HH, surgical treatment is not always performed.…”