Targetoid Hair Regrowth in Alopecia Areata: The Wave Theory

Río, E. Del

doi:10.1001/archderm.134.8.1042

Cited by 14 publications

(12 citation statements)

References 4 publications

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“…Hair loss may occur because proinflammatory cytokines interfere with the hair cycle, leading to the premature arrest of hair cycling with cessation of hair growth [5]. This concept may explain typical clinical features of AA, such as a progression pattern in centrifugal waves and spontaneous hair regrowth in concentric rings, suggesting the presence of soluble mediators within affected areas of the scalp [6]. T cells cloned from the lesional scalp also produce cytokines that inhibit the proliferation of keratinocytes, which may provide an additional mechanism for interference with the anagen phase of the hair cycle [7].…”

Section: Introductionmentioning

confidence: 99%

Serum Levels of Interleukin-2 in Patients with Alopecia Areata: Relationship with Clinical Type and Duration of the Disease

Kasumagić-Halilovic

Čavaljuga

Ovčina-Kurtović

et al. 2018

Skin Appendage Disord

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Background: Alopecia areata (AA) is a disease characterized by focally, nonscarring hair loss on the scalp or any hair-bearing surface. The etiology is unknown, although the evidence suggests that AA is an immunologically mediated disease. In the pathogenesis of AA, Th1 immune response is predominant. A special cytokine profile is created by Th1 cells, which disturbs the natural balance of the cytokine networks and leads to inflammatory reaction and follicle damage. Objective: The aim of our study was to evaluate serum concentrations of IL-2 in patients with AA and healthy subjects. We also examined a possible association between serum levels of IL-2, disease severity, and duration of AA. Methods: Sixty patients with AA and 20 healthy controls were enrolled in the study. Serum concentrations of IL-2 were measured using enzyme-linked immunoassay techniques. Results: Comparison of mean values of IL-2 has showed that serum concentrations of this cytokine are significantly higher in serum samples of AA patients in relation to the control group (22.2 ± 1.19 vs. 21.1 ± 2.68 pg/mL, respectively; p = 0.0142). No correlations were found between clinical type, duration of the disease, and serum levels of IL-2. Conclusion: Our findings support the evidence that elevation of serum IL-2 is associated with AA. The exact role of serum IL-2 in AA should be additionally investigated in future studies.

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Section: Introductionmentioning

confidence: 99%

Serum Levels of Interleukin-2 in Patients with Alopecia Areata: Relationship with Clinical Type and Duration of the Disease

Kasumagić-Halilovic

Čavaljuga

Ovčina-Kurtović

et al. 2018

Skin Appendage Disord

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“…In concentric growth, the repopulation adopts a target distribution. This entity has been described as more frequent after the application of topical treatments such as immunoterapy, 10 topical and intralesional steroids, 1,11,12 but there are also some cases of concentric regrowth without treatment 12 (Fig. 3a).…”

Section: Resultsmentioning

confidence: 99%

Unusual forms of alopecia areata in a Trichology Unit

Priego-Recio

Rodríguez‐Pichardo

Camacho‐Martínez

2013

Acad Dermatol Venereol

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“…This case highlights that hair regrowth in alopecia areata may follow different patterns, with these pictures demonstrating a striking targetoid pattern. Targetoid hair regrowth has previously been reported in alopecia areata 1,2 and various mechanisms for the development of this unusual pattern have been hypothesized. These include the possible centrifugal accumulation of corticosteroid cream and an underlying ‘earthquake’‐type mechanism, with a telogen wave causing the initial alopecia and then a hypothesized anagen wave potentially causing targetoid regrowth.…”

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confidence: 89%