Targeting Wee1 kinase as a therapeutic approach in Hematological Malignancies

Vakili-Samiani, Sajjad; Jalil, Abduladheem Turki; Abdelbasset, Walid Kamal; Yumashev, Alexei Valerievich; Karpisheh, Vahid; Jalali, Pooya; Adibfar, Sara; Ahmadi, Majid; Feizi, Abbas Ali Hosseinpour; Jadidi‐Niaragh, Farhad

doi:10.1016/j.dnarep.2021.103203

“…Innovative molecular therapy also aims to target leukemic cells' vulnerabilities more precisely. The use of conventional DNA-damage-based chemotherapy drugs in the past decades and the understanding of molecular mechanisms led to the discovery of potential new targets (e.g., WEE1 kinase) [38].…”

Section: Discussionmentioning

confidence: 99%

The Tumor Microenvironment-Dependent Transcription Factors AHR and HIF-1α Are Dispensable for Leukemogenesis in the Eµ-TCL1 Mouse Model of Chronic Lymphocytic Leukemia

Gonder

¹

,

Largeot

²

,

Gargiulo

³

et al. 2021

Cancers

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Chronic lymphocytic leukemia (CLL) is the most frequent leukemia in the elderly and is characterized by the accumulation of mature B lymphocytes in peripheral blood and primary lymphoid organs. In order to proliferate, leukemic cells are highly dependent on complex interactions with their microenvironment in proliferative niches. Not only soluble factors and BCR stimulation are important for their survival and proliferation, but also the activation of transcription factors through different signaling pathways. The aryl hydrocarbon receptor (AHR) and hypoxia-inducible factor (HIF)-1α are two transcription factors crucial for cancer development, whose activities are dependent on tumor microenvironment conditions, such as the presence of metabolites from the tryptophan pathway and hypoxia, respectively. In this study, we addressed the potential role of AHR and HIF-1α in chronic lymphocytic leukemia (CLL) development in vivo. To this end, we crossed the CLL mouse model Eµ-TCL1 with the corresponding transcription factor-conditional knock-out mice to delete one or both transcription factors in CD19+ B cells only. Despite AHR and HIF-1α being activated in CLL cells, deletion of either or both of them had no impact on CLL progression or survival in vivo, suggesting that these transcription factors are not crucial for leukemogenesis in CLL.

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“…A study in Iraq reported nearly similar results, where the resistant rates for penicillin antibiotics including ticarcillin, piperacillin and minocycline and trimethoprim+ sulfamthoxazole were 76.7%, 81.0%, 91.0% and 93.5%, respectively (26). Also, Abdul-Wahid, (24,(40)(41)(42)(43)(44)(45)(46)(47)(48)(49)(50)(51) in Iraq reported similar results where the resistant rates for ceftazidime, cefepime, ciprofloxacin, pefloxacin, gentamicin and aztreonam (64.0%, 63.5%, 59.0%, 58.5%, 63.0% and 57.0%), respectively. While, the other study in Iraq by Alkazrage (27) reported the resistant rates for imipenem, meropenem and colistin (35.0%, 31.0% and 21.8%), respectively.…”

Section: Discussionmentioning

confidence: 71%

Molecular study of quorum sensing and biofilm formation genes in pseudomonas aeruginosa isolated from UTIs patients

Al-Azawi

¹

,

Al-Shabbani

²

2022

ijhs

1

0

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Background: Urinary tract infection (UTI) is a common health problem in both community and nosocomial settings, affecting both men and women equally. Pseudomonas aeruginosa is an opportunistic human pathogen causing devastating acute and chronic infections in individuals with compromised immune systems. Biofilm is an architecture built mostly by autogenic extracellular polymeric substances which function as a scaffold to encase the bacteria together on surfaces, and to protect them from environmental stresses, impedes phagocytosis and thereby conferring the capacity for colonization and long-term persistence. So, the aim of this study to screen of some important quorum sensing and biofilm genes among pseudomonas aeruginosa isolated from UTIs patients. Methods: These study was conducted in Al-Qadisiyah province, Iraq at five major hospitals (AL-Diwanyia Teaching Hospital, Feminine and children teaching hospital, Afak General Hospital, AL-Hamzah General Hospital and AL-Shamiya General Hospital) during the period from (November, 2020 to June, 2021). A total of 800 urine samples were collected from male and females referring to five major hospitals. The age of the patients ranged from (1 to 80) years-old.

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“…A study in Iraq reported nearly similar results, where the resistant rates for penicillin antibiotics including ticarcillin, piperacillin and minocycline and trimethoprim+ sulfamthoxazole were 76.7%, 81.0%, 91.0% and 93.5%, respectively (26). Also, Abdul-Wahid, (24,(40)(41)(42)(43)(44)(45)(46)(47)(48)(49)(50)(51) in Iraq reported similar results where the resistant rates for ceftazidime, cefepime, ciprofloxacin, pefloxacin, gentamicin and aztreonam (64.0%, 63.5%, 59.0%, 58.5%, 63.0% and 57.0%), respectively. While, the other study in Iraq by Alkazrage ( 27) reported the resistant rates for imipenem, meropenem and colistin (35.0%, 31.0% and 21.8%), respectively.…”

Section: Discussionmentioning

confidence: 81%

Molecular study of quorum sensing and biofilm formation genes in Pseudomonas aeruginosa isolated from UTIs patients

Al-Azawi

¹

,

Al-Shabbani

²

2022

ijhs

0

View full text Add to dashboard Cite

Background: Urinary tract infection (UTI) is a common health problem in both community and nosocomial settings, affecting both men and women equally. Pseudomonas aeruginosa is an opportunistic human pathogen causing devastating acute and chronic infections in individuals with compromised immune systems. Biofilm is an architecture built mostly by autogenic extracellular polymeric substances which function as a scaffold to encase the bacteria together on surfaces, and to protect them from environmental stresses, impedes phagocytosis and thereby conferring the capacity for colonization and long-term persistence. So, the aim of this study to screen of some important quorum sensing and biofilm genes among pseudomonas aeruginosa isolated from UTIs patients. Methods: These study was conducted in Al-Qadisiyah province, Iraq at five major hospitals (AL-Diwanyia Teaching Hospital, Feminine and children teaching hospital, Afak General Hospital, AL-Hamzah General Hospital and AL-Shamiya General Hospital) during the period from (November, 2020 to June, 2021). A total of 800 urine samples were collected from male and females referring to five major hospitals. The age of the patients ranged from (1 to 80) years-old. Results: Sixty isolates were showed positive and identified as P. aeruginosa by using selective media, biochemical test system and VITEK-2 compact system.

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Targeting Wee1 kinase as a therapeutic approach in Hematological Malignancies

Cited by 42 publications

References 166 publications

The Tumor Microenvironment-Dependent Transcription Factors AHR and HIF-1α Are Dispensable for Leukemogenesis in the Eµ-TCL1 Mouse Model of Chronic Lymphocytic Leukemia

The Tumor Microenvironment-Dependent Transcription Factors AHR and HIF-1α Are Dispensable for Leukemogenesis in the Eµ-TCL1 Mouse Model of Chronic Lymphocytic Leukemia

Molecular study of quorum sensing and biofilm formation genes in pseudomonas aeruginosa isolated from UTIs patients

Molecular study of quorum sensing and biofilm formation genes in Pseudomonas aeruginosa isolated from UTIs patients

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