Targeting the Warburg effect: A revisited perspective from molecular mechanisms to traditional and innovative therapeutic strategies in cancer

Liao, Minru; Yao, Dahong; Wu, Lifeng; Luo, Chaodan; Wang, Zhiwen; Zhang, Jin; Liu, Bo

doi:10.1016/j.apsb.2023.12.003

Cited by 4 publications

(2 citation statements)

References 580 publications

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“…Indeed, it has been reported that overexpression of GLUTs correlates with aggressive tumor behavior since glycolytic-dominancy also known as "Warburg effect," is a key element for tumors growth and invasion. 34,35 Our findings are in line with what reported in literature, since it has been demonstrated that in pancreatic ductal adenocarcinoma cells, PON2 promoted cell proliferation by enhancing glucose transport, while in B cell acute lymphoblastic leukemia enabled glucose uptake by preventing stomatin-mediated inhibition of Glut1. 20 Finally, the loss of endogenous PON2 expression impaired key aspects of oxidative metabolism in lung adenocarcinoma cells, leading to the hindrance of cell proliferation.…”

Section: Discussionsupporting

confidence: 92%

Paraoxonase‐2 shRNA‐mediated gene silencing suppresses proliferation and migration, while promotes chemosensitivity in clear cell renal cell carcinoma cell lines

Schiavoni,

Emanuelli,

Campagna

et al. 2024

J of Cellular Biochemistry

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Clear cell renal cell carcinoma (ccRCC) represents the most common subtype of renal tumor. Despite recent advances in identifying novel target molecules, the prognosis of patients with ccRCC continues to be poor, mainly due to the lack of sensitivity to chemo‐ and radiotherapy and because of one‐third of renal cell carcinoma patients displays metastatic disease at diagnosis. Thus, identifying new molecules for early detection and for developing effective targeted therapies is mandatory. In this work, we focused on paraoxonase‐2 (PON2), an intracellular membrane‐bound enzyme ubiquitously expressed in human tissues, whose upregulation has been reported in a variety of malignancies, thus suggesting its possible role in cancer cell survival and proliferation. To investigate PON2 involvement in tumor cell metabolism, human ccRCC cell lines were transfected with plasmid vectors coding short harpin RNAs targeting PON2 transcript and the impact of PON2 silencing on cell viability, migration, and response to chemotherapeutic treatment was then explored. Our results showed that PON2 downregulation was able to trigger a decrease in proliferation and migration of ccRCC cells, as well as an enhancement of cell sensitivity to chemotherapy. Thus, taken together, data reported in this study suggest that the enzyme may represent an interesting therapeutic target for ccRCC.

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Section: Discussionsupporting

confidence: 92%

Paraoxonase‐2 shRNA‐mediated gene silencing suppresses proliferation and migration, while promotes chemosensitivity in clear cell renal cell carcinoma cell lines

Schiavoni,

Emanuelli,

Campagna

et al. 2024

J of Cellular Biochemistry

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“…The Warburg effect assumes a central role in the evolution of cancer cells, influencing the cellular energy metabolism and actively participating in the modulation of key transcriptional factors and proteins like FOXM1, p53, NFκB, HIF1α, and c-Myc [ 146 ]. Notably, glycolytic enzymes, including GLUTs, HKs, PFKs, LDHs, and PKM2, make substantial contributions to the development of cancer, with their elevated expression being associated with advanced tumor stages and the occurrence of metastasis.…”

Section: Altered Metabolism In Bone Metastasismentioning

confidence: 99%

Bridging the Gap in Understanding Bone Metastasis: A Multifaceted Perspective

Elaasser,

Arakil,

Mohammad

2024

IJMS

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The treatment of patients with advanced cancer poses clinical problems due to the complications that arise as the disease progresses. Bone metastases are a common problem that cancer patients may face, and currently, there are no effective drugs to treat these individuals. Prostate, breast, and lung cancers often spread to the bone, causing significant and disabling health conditions. The bone is a highly active and dynamic tissue and is considered a favorable environment for the growth of cancer. The role of osteoblasts and osteoclasts in the process of bone remodeling and the way in which their interactions change during the progression of metastasis is critical to understanding the pathophysiology of this disease. These interactions create a self-perpetuating loop that stimulates the growth of metastatic cells in the bone. The metabolic reprogramming of both cancer cells and cells in the bone microenvironment has serious implications for the development and progression of metastasis. Insight into the process of bone remodeling and the systemic elements that regulate this process, as well as the cellular changes that occur during the progression of bone metastases, is critical to the discovery of a cure for this disease. It is crucial to explore different therapeutic options that focus specifically on malignancy in the bone microenvironment in order to effectively treat this disease. This review will focus on the bone remodeling process and the effects of metabolic disorders as well as systemic factors like hormones and cytokines on the development of bone metastases. We will also examine the various therapeutic alternatives available today and the upcoming advances in novel treatments.

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Introduction to Neoplasia

Argyris,

Herzberg

2024

Reference Module in Biomedical Sciences

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Targeting the Warburg effect: A revisited perspective from molecular mechanisms to traditional and innovative therapeutic strategies in cancer

Cited by 4 publications

References 580 publications

Paraoxonase‐2 shRNA‐mediated gene silencing suppresses proliferation and migration, while promotes chemosensitivity in clear cell renal cell carcinoma cell lines

Paraoxonase‐2 shRNA‐mediated gene silencing suppresses proliferation and migration, while promotes chemosensitivity in clear cell renal cell carcinoma cell lines

Bridging the Gap in Understanding Bone Metastasis: A Multifaceted Perspective

Introduction to Neoplasia

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