Biochemical Pharmacology volume 80, issue 5, P624-637 2010 DOI: 10.1016/j.bcp.2010.04.029 View full text
Gajanan S. Inamdar, SubbaRao V. Madhunapantula, Gavin P. Robertson

Abstract: AbstractThe Mitogen Activated Protein Kinase (MAPK) pathway plays a key role in melanoma development making it an important therapeutic target. In normal cells, the tightly regulated pathway relays extracellular signals from cell membrane to nucleus via a cascade of phosphorylation events. In melanomas, dysregulation of the MAPK pathway occurs frequently due to activating mutations in the B-RAF and RAS genes or other genetic or epigenetic modifications, leading to increased signaling activity promoting cell p…

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