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Cited by 3 publications
(3 citation statements)
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“…Two families of histone demethylases (KDMs) have been discovered: flavin-dependent lysine-specific demethylases and JmjC domain-containing KDMs. The flavin-dependent KDM family includes LSD1 (KDM1A/AOF2) and LSD2 (KDM1B/AOF1) [ 12 ]. LSD1 has been shown to be overexpressed in colorectal cancer and to promote the growth and invasion of colorectal cancer [ 16 , 17 ].…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…Two families of histone demethylases (KDMs) have been discovered: flavin-dependent lysine-specific demethylases and JmjC domain-containing KDMs. The flavin-dependent KDM family includes LSD1 (KDM1A/AOF2) and LSD2 (KDM1B/AOF1) [ 12 ]. LSD1 has been shown to be overexpressed in colorectal cancer and to promote the growth and invasion of colorectal cancer [ 16 , 17 ].…”
Section: Discussionmentioning
confidence: 99%
“…The common demethylases include histone demethylase containing the jumonji C (JmjC) domain [ 8 ] and FAD-dependent lysine-specific demethylase (LSDs), including LSD1 and LSD2 [ 9 11 ]. LSD2 plays important roles in gene silencing, transcription factor activity regulation, and cell cycle regulation in the occurrence and development of many types of tumors [ 10 , 12 14 ]. Moreover, LSD2 overexpression predicts aggressive tumor biology and poor prognosis [ 15 ].…”
Section: Introductionmentioning
confidence: 99%
“…LSD2 has been noted to be overexpressed in several malignancies such as colorectal adenocarcinoma, small cell lung cancer and breast cancer [16, 17, 18]. Recent studies with breast cancer cell lines showed that overexpression of LSD2 led to increased cell proliferation and oncogenic transformation, but decreased cellular motility and invasion [15].…”
Section: Introductionmentioning
confidence: 99%