Targeting human brain cancer stem cells by curcumin-loaded nanoparticles grafted with anti-aldehyde dehydrogenase and sialic acid: Colocalization of ALDH and CD44

Kuo, Yung‐Chih; Wang, Li-Jung; Rajesh, Rajendiran

doi:10.1016/j.msec.2019.04.065

Cited by 49 publications

(37 citation statements)

References 49 publications

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“…It is worth mentioning that these properties are influenced when chitosan is functionalized, and they depend on the added molecules. For example, Kuo and collaborators, recently developed chitosan-PLGA nanoparticles grafted with anti-aldehyde dehydrogenase and sialic acid for brain tumortargeted delivery of curcumin (Kuo et al, 2019). They promoted the BBB permeation through N-acetylglucosamine.…”

Section: Drug Delivery To Cnsmentioning

confidence: 99%

Potential of Chitosan and Its Derivatives for Biomedical Applications in the Central Nervous System

Ojeda-Hernández

Canales-Aguirre

Matías‐Guiu

et al. 2020

Front. Bioeng. Biotechnol.

119

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It is well known that the central nervous system (CNS) has a limited regenerative capacity and that many therapeutic molecules cannot cross the blood brain barrier (BBB). The use of biomaterials has emerged as an alternative to overcome these limitations. For many years, biomedical applications of chitosan have been studied due to its remarkable biological properties, biocompatibility, and high versatility. Moreover, the interest in this biomaterial for CNS biomedical implementation has increased because of its ability to cross the BBB, mucoadhesiveness, and hydrogel formation capacity. Several chitosanbased biomaterials have been applied with promising results as drug, cell and gene delivery vehicles. Moreover, their capacity to form porous scaffolds and to bear cells and biomolecules has offered a way to achieve neural regeneration. Therefore, this review aims to bring together recent works that highlight the potential of chitosan and its derivatives as adequate biomaterials for applications directed toward the CNS. First, an overview of chitosan and its derivatives is provided with an emphasis on the properties that favor different applications. Second, a compilation of works that employ chitosan-based biomaterials for drug delivery, gene therapy, tissue engineering, and regenerative medicine in the CNS is presented. Finally, the most interesting trends and future perspectives of chitosan and its derivatives applications in the CNS are shown.

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Section: Drug Delivery To Cnsmentioning

confidence: 99%

Potential of Chitosan and Its Derivatives for Biomedical Applications in the Central Nervous System

Ojeda-Hernández

Canales-Aguirre

Matías‐Guiu

et al. 2020

Front. Bioeng. Biotechnol.

119

View full text Add to dashboard Cite

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“…Polymeric nanoparticles are the nanosystems with the highest reported usage of chitosan coating for brain delivery. For example, in several studies, chitosan-modified PLGA nanoparticles were loaded with chemotherapeutic drugs for the treatment of glioblastomas and brain cancer in in vitro and in vivo models [16,17,86]. These studies demonstrated higher cytotoxicity against malignant cells, more selectivity, and better absorption of nanoparticles by cancer cells, as well as a greater reach of brain tissue when their surfaces were modified with chitosan.…”

Section: Polymeric Nanoparticlesmentioning

confidence: 99%

“…The enhancing effect of chitosan was associated with a mucoadhesion linked to a longer residence time of the system in the olfactory mucosa, the electrostatic interaction with the BBB cells, the opening of tight junctions, and the control of release rate of drugs. Additionally, some nanoparticles were functionalized with sialic acid to promote the permeation through the BBB, with anti-aldehyde dehydrogenase [16] or folic acid [86] to target brain cancer stem cells.…”

Section: Polymeric Nanoparticlesmentioning

confidence: 99%

“…Chitosan is a polymer natural widely utilized in different applications and approved for human use; it is a biodegradable, biocompatible, non-toxic, non-allergenic, and low-priced biomaterial; thus, chitosan is a suitable material for medical purposes [15]. Numerous studies have evaluated chitosan-coated nanosystems for the transportation of therapeutic compounds for the potential treatment of Alzheimer´s disease, Parkinson's disease, gliomas, cerebral ischemia, and schizophrenia [16][17][18][19][20][21][22][23][24].…”

Section: Introductionmentioning

confidence: 99%

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A Reevaluation of Chitosan-Decorated Nanoparticles to Cross the Blood-Brain Barrier

et al. 2020

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The blood-brain barrier (BBB) is a sophisticated and very selective dynamic interface composed of endothelial cells expressing enzymes, transport systems, and receptors that regulate the passage of nutrients, ions, oxygen, and other essential molecules to the brain, regulating its homeostasis. Moreover, the BBB performs a vital function in protecting the brain from pathogens and other dangerous agents in the blood circulation. Despite its crucial role, this barrier represents a difficult obstacle for the treatment of brain diseases because many therapeutic agents cannot cross it. Thus, different strategies based on nanoparticles have been explored in recent years. Concerning this, chitosan-decorated nanoparticles have demonstrated enormous potential for drug delivery across the BBB and treatment of Alzheimer’s disease, Parkinson’s disease, gliomas, cerebral ischemia, and schizophrenia. Our main objective was to highlight the high potential of chitosan adsorption to improve the penetrability through the BBB of nanoformulations for diseases of CNS. Therefore, we describe the BBB structure and function, as well as the routes of chitosan for crossing it. Moreover, we define the methods of decoration of nanoparticles with chitosan and provide numerous examples of their potential utilization in a variety of brain diseases. Lastly, we discuss future directions, mentioning the need for extensive characterization of proposed nanoformulations and clinical trials for evaluation of their efficacy.

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“…Methylation of the O -methylguanine-DNA methyltransferase (MGMT) promoter is associated with better response to temozolomide and prolonged survival (Hegi, 2004 #304). Furthermore, the longstanding obstacle of the delivery of chemotherapy agents to the central nervous system due to the presence of the blood brain barrier, may be overcome by a promising novel drug delivery system that has been developed, involving curcumin-loaded chitosan polylactic-coglycolic acid nanoparticles modified with sialic acid, to penetrate the blood brain barrier with antialdehyde dehydrogenase to target the CSCs (Kuo, Wang et al 2019).…”

Section: Introductionmentioning

confidence: 99%

Therapeutic Targeting of Cancer Stem Cells in Human Glioblastoma by Manipulating the Renin-angiotensin System

Tan¹,

Roth²,

Wickremesekera³

et al. 2019

Preprint

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Patients with glioblastoma (GB), a highly aggressive brain tumor, have a median survival of 14.6 months following neurosurgical resection with adjuvant chemoradiotherapy. Quiescent GB cancer stem cells (CSCs) invariably cause local recurrence. These GB CSCs that can be identified by embryonic stem cell markers express components of the renin-angiotensin system and are associated with circulating CSCs. Despite the presence of circulating CSCs, GB rarely develops distant metastasis outside the central nervous system. This paper reviews the current literature on GB growth inhibition in relation to CSCs, circulating CSCs, the RAS and the novel therapeutic approach by repurposing drugs that target the renin-angiotensin system to improve overall symptom-free survival and maintain quality of life.

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Targeting human brain cancer stem cells by curcumin-loaded nanoparticles grafted with anti-aldehyde dehydrogenase and sialic acid: Colocalization of ALDH and CD44

Cited by 49 publications

References 49 publications

Potential of Chitosan and Its Derivatives for Biomedical Applications in the Central Nervous System

Potential of Chitosan and Its Derivatives for Biomedical Applications in the Central Nervous System

A Reevaluation of Chitosan-Decorated Nanoparticles to Cross the Blood-Brain Barrier

Therapeutic Targeting of Cancer Stem Cells in Human Glioblastoma by Manipulating the Renin-angiotensin System

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