2004
DOI: 10.1001/jama.292.3.377
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Targeting High-Risk Young Patients for Statin Therapy

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Cited by 7 publications

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“…23 Regarding possible effects on growth and maturation, the current data are reassuring in that no clinically relevant effects have been observed. 8,9,24 Again, the short duration of the available clinical trials is a concern; possible adverse effects on growth and/or maturation may not be seen in trials lasting 2 years or less. Use of statins in females of childbearing age should be avoided because we have no systematic data on the incidence of birth defects while taking these drugs during pregnancy.…”
Section: Pediatric Issues and Concernsmentioning
confidence: 99%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
“…23 Regarding possible effects on growth and maturation, the current data are reassuring in that no clinically relevant effects have been observed. 8,9,24 Again, the short duration of the available clinical trials is a concern; possible adverse effects on growth and/or maturation may not be seen in trials lasting 2 years or less. Use of statins in females of childbearing age should be avoided because we have no systematic data on the incidence of birth defects while taking these drugs during pregnancy.…”
Section: Pediatric Issues and Concernsmentioning
confidence: 99%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
“…1 Lifestyle changes alone may have a minimal impact on this genetic dyslipidemia, and the more potent options of drugs or blood apheresis to remove LDL have their own issues. 2 After a number of clinical trials that have reported significant coronary risk reductions, there can be no question that use of the lipid medications called statins must be considered as part of the treatment of high-risk adults, such as those who present with FH.…”
mentioning
confidence: 99%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.