Targeted therapies against breast cancer: Clinical perspectives, obstacles and new opportunities

Cutting-edge approaches for targeted drug delivery in breast cancer: beyond conventional therapies

“…63 More recently, a study involving breast cancer patients demonstrated the enhanced efficacy of Abraxane® compared to conventional paclitaxel formulations. 64,65…”

“…Nanoscale Advances the enhanced efficacy of Abraxane® compared to conventional paclitaxel formulations. 64,65 The Au + ions with a positive charge within gold nanoparticles (GNPs) play a pivotal role in their function as carriers that specically target tumors. GNPs attract negatively charged biomolecules via electrostatic interactions.…”

Targeting brain tumors with innovative nanocarriers: bridging the gap through the blood-brain barrier

“…In addition to their small size, nanocarrier-based drug therapies for GBM offer crucial advantages such as a low toxicity profile, high target specificity, and controlled release, making them highly beneficial [ 27 ]. Indeed, the physicochemical characteristics of nanotechnology-based medicines are imperative factors for their action within the body [ 26 , 28 ]. The shape and diameter of nanomedicine, along with its surface factors like smoothness, charge, and chemistry, primarily affect the pharmacokinetic and pharmacodynamic behavior, comprising drug accumulation in the brain [ 29 , 30 ].…”

“…Studies also affirmed that disease conditions could alter both BBB physiology and nanomedicine delivery in vivo [ 28 , 32 , 33 ]. Houston and colleagues employed mice with spontaneous brain tumors in a critically vital study to underline the relationship between BBB permeability with nano drugs and tumor growth.…”