2020 DOI: 10.20944/preprints202008.0712.v1 View full text Preprint
Veronika Dill, Aline Zimmer, Martin Beer, Michael Eschbaumer

Abstract: Foot-and-mouth disease virus (FMDV) causes the highly contagious foot-and-mouth disease, which is characterized by the appearance of vesicles in and around the mouth and feet of cloven-hoofed animals. BHK21 cells are the cell line of choice for the propagation of FMDV for vaccine production world-wide but vary in their susceptibility for different FMDV strains. Previous studies showed that the FMDV resistance of a certain BHK cell line can be overcome by using a closely related but permissive cell line for the…

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