Targeted Library of Phosphonic-Type Inhibitors of Human Neutrophil Elastase
Karolina Torzyk-Jurowska,
Jaroslaw Ciekot,
Lukasz Winiarski
Abstract:Despite many years of research, human neutrophil elastase (HNE) still remains an area of interest for many researchers. This multifunctional representative of neutrophil serine proteases is one of the most destructive enzymes found in the human body which can degrade most of the extracellular matrix. Overexpression or dysregulation of HNE may lead to the development of several inflammatory diseases. Previously, we presented the HNE inhibitor with kinact/KI value over 2,000,000 [M−1s−1]. In order to optimize it… Show more
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