2019
DOI: 10.1080/15548627.2019.1590519
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Targeted interplay between bacterial pathogens and host autophagy

Abstract: Due to the critical role played by autophagy in pathogen clearance, pathogens have developed diverse strategies to subvert it. Despite previous key findings of bacteria-autophagy interplay, asystems-level insight into selective targeting by the host and autophagy modulation by the pathogens is lacking. We predicted potential interactions between human autophagy proteins and effector proteins from 56 pathogenic bacterial species by identifying bacterial proteins predicted to have recognition motifs for selectiv… Show more

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Cited by 41 publications
(53 citation statements)
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“…The next step is the interaction prediction. In this step, we compare the annotated domains and motifs from the compiled bacterial and host proteins with the databases DOMINE [38] and ELM [39], which respectively contain high-confidence lists of domain-domain and domain-motif pairs already known to interact [18,40,41]. This procedure helps determine which bacterial proteins via their respective domains interact with host receptor proteins.…”
Section: Pipeline Descriptionmentioning
confidence: 99%
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“…The next step is the interaction prediction. In this step, we compare the annotated domains and motifs from the compiled bacterial and host proteins with the databases DOMINE [38] and ELM [39], which respectively contain high-confidence lists of domain-domain and domain-motif pairs already known to interact [18,40,41]. This procedure helps determine which bacterial proteins via their respective domains interact with host receptor proteins.…”
Section: Pipeline Descriptionmentioning
confidence: 99%
“…This is performed by excluding interactions involving motifs outside disordered interactions (using IUPRED [44]) and/or within globular domains (from PFAM [45], InterPro [46]). Some studies such as [18][19][20] have already successfully used this structure-based approach to predict PPIs between microbial and host proteins, and validated the PPIs experimentally.…”
Section: Pipeline Descriptionmentioning
confidence: 99%
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“…In response to various cellular stress, activation of autophagy is crucial for maintaining cellular energy levels through synthesis, degradation and recycle of constituents. Induction of autophagy serves as a cell defence mechanism against intracellular pathogenic microorganisms (Sudhakar, Jacomin et al, 2019). Several microbes such as Listeria monocytogenes have been shown to stimulate formation of autophagosomes, which in turn initiates bacterial degradation (Huang & Brumell, 2014).…”
mentioning
confidence: 99%