Targeted doxorubicin nanotherapy strongly suppressing growth of multidrug resistant tumor in mice

Nguyen, Dai Hai; Lee, Jung Seok; Bae, Jin Woo; Choi, Jong Hoon; Lee, Yunki; Son, Joo Young; Парк, Ки Донг

doi:10.1016/j.ijpharm.2015.08.083

Cited by 43 publications

(16 citation statements)

References 37 publications

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“…It is stated that NPs in the range of 100–200 nm have the highest potential to extend circulation time in the bloodstream because they are small enough to avoid mechanical filtration by the spleen, but large enough to avoid selective uptake in the liver. Small size permits NPs passively targeting tumor cells through the enhanced permeability and retention (EPR) effect, improving intracellular accumulation and localization of NPs in tumor area [21, 22]. Another important parameter that controls the stability of NPs in physiological condition is zeta potential.…”

Section: Resultsmentioning

confidence: 99%

Development and In Vitro Evaluation of Liposomes Using Soy Lecithin to Encapsulate Paclitaxel

Nguyễn

Nguyen

2017

International Journal of Biomaterials

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The formulation of a potential delivery system based on liposomes (Lips) formulated from soy lecithin (SL) for paclitaxel (PTX) was achieved (PTX-Lips). At first, PTX-Lips were prepared by thin film method using SL and cholesterol and then were characterized for their physiochemical properties (particle size, polydispersity index, zeta potential, and morphology). The results indicated that PTX-Lips were spherical in shape with a dynamic light scattering (DLS) particle size of 131 ± 30.5 nm. Besides, PTX was efficiently encapsulated in Lips, 94.5 ± 3.2% for drug loading efficiency, and slowly released up to 96 h, compared with free PTX. More importantly, cell proliferation kit I (MTT) assay data showed that Lips were biocompatible nanocarriers, and in addition the incorporation of PTX into Lips has been proven successful in reducing the toxicity of PTX. As a result, development of Lips using SL may offer a stable delivery system and promising properties for loading and sustained release of PTX in cancer therapy.

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Section: Resultsmentioning

confidence: 99%

Development and In Vitro Evaluation of Liposomes Using Soy Lecithin to Encapsulate Paclitaxel

Nguyễn

Nguyen

2017

International Journal of Biomaterials

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“…Pluronic polymer-based micelles, to which folic acid (FA), redox-sensitive thiol groups and the anti-cancer drug doxorubicin (DOX) are chemically conjugated with pH-sensitive linkers, could be successfully delivered into multidrug-resistant (MDR) tumors in mice and exerted high cytotoxicity in the DOX-resistant MDR tumors by bypassing MDR efflux [57]. The carboxylate graphene oxide (GO)-based nanocarrier was multifunctionalized by poly(ethylene glycol) (PEG) terminated with an amino group and an FA group (FA–PEG–NH 2 ) via the amidation reaction.…”

Section: Application Of Engineered Biological Molecules To Nanobio/bimentioning

confidence: 99%

Biomolecular engineering for nanobio/bionanotechnology

Nagamune

2017

Nano Convergence

100

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Biomolecular engineering can be used to purposefully manipulate biomolecules, such as peptides, proteins, nucleic acids and lipids, within the framework of the relations among their structures, functions and properties, as well as their applicability to such areas as developing novel biomaterials, biosensing, bioimaging, and clinical diagnostics and therapeutics. Nanotechnology can also be used to design and tune the sizes, shapes, properties and functionality of nanomaterials. As such, there are considerable overlaps between nanotechnology and biomolecular engineering, in that both are concerned with the structure and behavior of materials on the nanometer scale or smaller. Therefore, in combination with nanotechnology, biomolecular engineering is expected to open up new fields of nanobio/bionanotechnology and to contribute to the development of novel nanobiomaterials, nanobiodevices and nanobiosystems. This review highlights recent studies using engineered biological molecules (e.g., oligonucleotides, peptides, proteins, enzymes, polysaccharides, lipids, biological cofactors and ligands) combined with functional nanomaterials in nanobio/bionanotechnology applications, including therapeutics, diagnostics, biosensing, bioanalysis and biocatalysts. Furthermore, this review focuses on five areas of recent advances in biomolecular engineering: (a) nucleic acid engineering, (b) gene engineering, (c) protein engineering, (d) chemical and enzymatic conjugation technologies, and (e) linker engineering. Precisely engineered nanobiomaterials, nanobiodevices and nanobiosystems are anticipated to emerge as next-generation platforms for bioelectronics, biosensors, biocatalysts, molecular imaging modalities, biological actuators, and biomedical applications.

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“…Nanoparticles in the range of 100 to 200 nm can avoid mechanical filtration by the spleen due to their small size but are also large enough to avoid selective uptake in the liver, and thus their bloodstream circulation time can be extended. Furthermore, due to their small size and a mechanism called the enhanced permeability and retention (EPR) effect, the passive targeting of tumor cells is possible, and their intracellular accumulation and localization in the tumor area are improved [24,25]. The ζ-potential is another important parameter, as negatively charged nanoparticles are not only significantly less phagocytized than positive ones but also possess improved physical stability [26].…”

Section: Introductionmentioning

confidence: 99%

Effects of Bioactive Marine-Derived Liposomes on Two Human Breast Cancer Cell Lines

Elkhoury

Barbieux

et al. 2020

Marine Drugs

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Breast cancer is the leading cause of death from cancer among women. Higher consumption of dietary marine n-3 long-chain polyunsaturated fatty acids (LC-PUFAs) is associated with a lower risk of breast cancer. Eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) are two n-3 LC-PUFAs found in fish and exert anticancer effects. In this study, natural marine-derived lecithin that is rich in various polyunsaturated fatty acids (PUFAs) was extracted from salmon heads and transformed into nanoliposomes. These nanoliposomes were characterized and cultured with two breast cancer lines (MCF-7 and MDA-MB-231). The nanoliposomes decreased the proliferation and the stiffness of both cancer cell types. These results suggest that marine-derived lecithin possesses anticancer properties, which may have an impact on developing new liposomal delivery strategies for breast cancer treatment.

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Targeted doxorubicin nanotherapy strongly suppressing growth of multidrug resistant tumor in mice

Cited by 43 publications

References 37 publications

Development and In Vitro Evaluation of Liposomes Using Soy Lecithin to Encapsulate Paclitaxel

Development and In Vitro Evaluation of Liposomes Using Soy Lecithin to Encapsulate Paclitaxel

Biomolecular engineering for nanobio/bionanotechnology

Effects of Bioactive Marine-Derived Liposomes on Two Human Breast Cancer Cell Lines

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