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Cited by 544 publications
(575 citation statements)
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References 30 publications
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“…The JNK cascade is well known to play a key role in programmed cell death (Karin and Gallagher, 2005), which might explain the positive role of SHIP-1 in protecting leukemic cells from ROS-induced apoptosis. It is also interesting to note that if SHIP-1 À/À mice exhibit substantial increase in the percentage of circulating monocytes and mature neutrophiles, these also reveal a concomitant decrease in the percentage of circulating lymphocytes (Helgason et al, 1998), suggesting that SHIP-1 might have a key effect on lymphocyte survival, which is totally in agreement with our results. Further works are needed to elucidate SHIP-1 antiapoptotic role, which appears to be highly cell-type dependent.…”
Section: Discussionsupporting
confidence: 91%
See 1 more Smart Citation
“…The JNK cascade is well known to play a key role in programmed cell death (Karin and Gallagher, 2005), which might explain the positive role of SHIP-1 in protecting leukemic cells from ROS-induced apoptosis. It is also interesting to note that if SHIP-1 À/À mice exhibit substantial increase in the percentage of circulating monocytes and mature neutrophiles, these also reveal a concomitant decrease in the percentage of circulating lymphocytes (Helgason et al, 1998), suggesting that SHIP-1 might have a key effect on lymphocyte survival, which is totally in agreement with our results. Further works are needed to elucidate SHIP-1 antiapoptotic role, which appears to be highly cell-type dependent.…”
Section: Discussionsupporting
confidence: 91%
“…Hematopoietic stem cells from SHIP-1 À/À mice displayed increased colony formation in response to interleukin-3, granulocyte macrophage colony-stimulating factor, granulocyte colony-stimulating factor and steel factor, indicating that SHIP-1 acts as a negative regulator of survival and proliferation responses mediated by these cytokines. Furthermore, SHIP-1-deficient mice died prematurely secondary to lung infiltration by myeloid and granulocytic cells (Helgason et al, 1998).…”
Section: Introductionmentioning
confidence: 99%
“…The tumor suppressor PTEN serves as the 3 0 phosphoinositide phosphatase, and is frequently inactivated by epigenetic silencing (Dahia et al, 1999). SHIP-1 is a 5 0 phosphoinositide phosphatase, expressed exclusively in hematopoietic cells Helgason et al, 1998;Krystal, 2000). We found that PTEN levels were variably decreased in late-stage MDS.…”
Section: Resultsmentioning
confidence: 72%
“…Expressed specifically in hematopoietic cells, SHIP-1 hydrolyzes the 5 0 phosphate of PI-(3,4,5)P 3 (Geier et al, 1997). To date, there is no evidence of SHIP-1 acting as a tumor suppressor, although such a role in myeloid cells has been supported by abnormalities in SHIP-1-deficient mice (Helgason et al, 1998). We therefore chose to investigate the PI 3 0 kinase-PTEN/SHIP-1-Akt pathway in MDS.…”
Section: Introductionmentioning
confidence: 99%
“…SHIP1 is a 145-kDa protein mainly expressed in hemopoietic cells (Liu et al, 1998) playing a negative regulatory role in hemopoiesis (Helgason et al, 1998) and immune response (Coggeshall, 1998;Hunter and Avalos, 1998) by modulating PtdIns(3,4,5)P 3 levels (Scharenberg et al, 1998) and Ras/mitogen-activated protein kinase (MAPK) activity (Tridandapani et al, 1998). SHIP2 is a 160-kDa protein sharing several properties with SHIP1 including catalytic activity (Scharenberg et al, 1998) and binding to Shc after cell stimulation (Habib et al, 1998;Muraille et al, 1999Muraille et al, , 2000.…”
mentioning
confidence: 99%