2006
DOI: 10.1073/pnas.0600161103
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Abstract: Reduced intake of nutrients [calorie restriction (CR)] extends longevity in organisms ranging from yeast to mammals. Mutations affecting somatotropic, insulin, or homologous signaling pathways can increase life span in worms, flies, and mice, and there is considerable evidence that reduced secretion of insulin-like growth factor I and insulin are among the mechanisms that mediate the effects of CR on aging and longevity in mammals. In the present study, mice with targeted disruption of the growth hormone (GH) … Show more

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Cited by 289 publications
(279 citation statements)
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“…It was previously reported that the antiaging and prolongevity actions of CR were attenuated in long‐lived GH receptor (GHR) KO mice (Bonkowski et al ., 2006). Visceral fat removal elevated the respiratory quotient in GHRKO mice, but had the opposite effect in WT mice (Masternak et al ., 2012).…”
Section: Discussionmentioning
confidence: 99%
“…It was previously reported that the antiaging and prolongevity actions of CR were attenuated in long‐lived GH receptor (GHR) KO mice (Bonkowski et al ., 2006). Visceral fat removal elevated the respiratory quotient in GHRKO mice, but had the opposite effect in WT mice (Masternak et al ., 2012).…”
Section: Discussionmentioning
confidence: 99%
“…The extent to which these genes interact with CR-regulated pathways is unclear (Miller et al, 2002;Tsuchiya et al, 2004;Bonkowski et al, 2006;Swindell, 2007). However, some evidence suggests that such aging genes are likely to be highly connected within biological networks (Ferrarini et al, 2005;Curtis et al, 2006).…”
Section: Other "Aging Genes" Lack Unique Network Propertiesmentioning
confidence: 99%
“…In the field of aging research, epistatic analysis using survival curves and average lifespan has become a standard method of determining the independence of genes and pathways (Bartke et al 2001;Bonkowski et al 2006;Braeckman et al 2000;Clancy et al 2002;Kenyon et al 1993;Lakowski and Hekimi 1998;Tissenbaum and Ruvkun 1998). As such, this study uses a similar epistatic design.…”
Section: Introductionmentioning
confidence: 99%