Targeted delivery of honokiol by zein/hyaluronic acid core-shell nanoparticles to suppress breast cancer growth and metastasis

Zhang, Qi; Wang, Jing; Liú, Dan; Zhu, Wenquan; Guan, Shuang; Fan, Li; Cai, Defu

doi:10.1016/j.carbpol.2020.116325

Cited by 60 publications

(47 citation statements)

References 49 publications

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“…Application Encapsulated Substance Reference zein/chitosan nano complex oral drug and food delivery curcumin and resveratrol [97] zein/carrageenan oral drug delivery curcumin and piperine coenzyme Q10 and piperine [98,99] hydrophilic whey isolate/zein oral drug delivery curcumin [100] zein/carrageenan/tween 80 drug delivery curcumin [101] pectin from Akebia trifoliata var. Australis fruit peel and zein drug and food delivery curcumin [102] deamidated zein peptide drug and food delivery curcumin [37] zein/soybean polysaccharide drug delivery lutein [103] zein/caseinate oral and parenteral drug delivery simvastatin [44] zein/gold nanoparticles antibacterial and larvicidal the whole nanocomposite [104] zein/lactoferrin drug delivery 7,8-dihydroxyflavone [105] zein/tea saponins food and drug delivery lutein [106] solid zein nanoparticles drug delivery Gene delivery maytansine PTEN and TRAIL genes [107,108] hollow zein nanoparticles food and drug delivery curcumin [109] zein/CMC postharvest fruit preservation natamycin [56] zein/bacterial cellulose preservative and packaging silymarin [110] zein/sodium deoxycholate cytotoxic drug delivery paclitaxel [111] lipid/zein core-shell nanocomposite targeted pulmonary drug delivery all-trans retinoic acid and genistein [112] mesoporous silica nanoparticles coated with zein polycarbolactone mixture antimicrobial photodynamic therapy methylene blue [113] zein/phosphatidylcholine hybrid nanoparticles cancer photodynamic therapy indocyanine green [114] zein/lactoferrin functional food delivery 7,8-dihydroxyflavone [105] zein/hyaluronic acid targeted drug delivery curcumin honokiol [115,116] zein-cellulose nanocrystals core-shell nanoparticles functional food delivery curcumin [117] zein nanoparticles oral drug delivery resveratrol [118] polyamine modified zein pest management avermectin [119] zein/pluronic F68 nanoparticles pest management limonene and carvacrol [120] zein/fucoidan nanocomplex oral drug delivery curcumin…”

Section: Zein Based Nanocomposite Platformmentioning

confidence: 99%

Surface-Tailored Zein Nanoparticles: Strategies and Applications

et al. 2021

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Plant-derived proteins have emerged as leading candidates in several drug and food delivery applications in diverse pharmaceutical designs. Zein is considered one of the primary plant proteins obtained from maize, and is well known for its biocompatibility and safety in biomedical fields. The ability of zein to carry various pharmaceutically active substances (PAS) position it as a valuable contender for several in vitro and in vivo applications. The unique structure and possibility of surface covering with distinct coating shells or even surface chemical modifications have enabled zein utilization in active targeted and site-specific drug delivery. This work summarizes up-to-date studies on zein formulation technology based on its structural features. Additionally, the multiple applications of zein, including drug delivery, cellular imaging, and tissue engineering, are discussed with a focus on zein-based active targeted delivery systems and antigenic response to its potential in vivo applicability.

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Section: Zein Based Nanocomposite Platformmentioning

confidence: 99%

Surface-Tailored Zein Nanoparticles: Strategies and Applications

et al. 2021

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“…The active binding of hyaluronan to the CD44 receptor allowed the targeted delivery of the NPs to the breast cancer cells, followed by the release of drugs induced by pH and environmental stimuli. Zhang et al [23] reported the controlled release of a conjugated bioactive biphenolic compound (honokiol) from core-shell NPs of zein-hyaluronic acid while the in vivo study showed enhanced antitumor and antimetastatic effects in the tumor-bearing mice.…”

Section: Core-shell Nanoparticlesmentioning

confidence: 99%

Development of Polymer-Assisted Nanoparticles and Nanogels for Cancer Therapy: An Update

Neerooa

Ooi

Shameli

et al. 2021

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With cancer remaining as one of the main causes of deaths worldwide, many studies are undergoing the effort to look for a novel and potent anticancer drug. Nanoparticles (NPs) are one of the rising fields in research for anticancer drug development. One of the key advantages of using NPs for cancer therapy is its high flexibility for modification, hence additional properties can be added to the NPs in order to improve its anticancer action. Polymer has attracted considerable attention to be used as a material to enhance the bioactivity of the NPs. Nanogels, which are NPs cross-linked with hydrophilic polymer network have also exhibited benefits in anticancer application. The characteristics of these nanomaterials include non-toxic, environment-friendly, and variable physiochemical properties. Some other unique properties of polymers are also attributed by diverse methods of polymer synthesis. This then contributes to the unique properties of the nanodrugs. This review article provides an in-depth update on the development of polymer-assisted NPs and nanogels for cancer therapy. Topics such as the synthesis, usage, and properties of the nanomaterials are discussed along with their mechanisms and functions in anticancer application. The advantages and limitations are also discussed in this article.

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“…19 Green synthesis of natural polymers for biomedical application is global recommendation by virtue of its minimized toxicity, recyclable properties, 20 sustainable purposes, and economic trends. 21,22 Zein nanospheres (ZN NSs) are promising delivery systems because of their plant provenance and process of preparation. ZN is obtained from corn 23 and is safe, non-toxic, FDA-approved, histocompatible, and does not inducing celiac disease or autoimmune responses.…”

Section: Introductionmentioning

confidence: 99%

“…ZN is obtained from corn 23 and is safe, non-toxic, FDA-approved, histocompatible, and does not inducing celiac disease or autoimmune responses. 22,24,25 The aim of the current study was to investigate the potential of a PTS-ZN NSs formulation in ameliorating cytotoxicity proapoptotic and oxidative stress MCF7 cells.…”

Section: Introductionmentioning

confidence: 99%