Targeted delivery of autoantigen to dendritic cells prevents development of spontaneous uveitis
Izabela P. Klaska,
Tian Yu,
Rosie Fordyce
et al.
Abstract:Restoration of immunological tolerance to self antigens has been a major drive in understanding the mechanisms of, and developing new treatments for, autoimmune and autoinflammatory disease. Sessile dendritic cells (DC) are considered the main instruments underpinning immunological tolerance particularly the CD205+ (DEC205+) cDC1 subset in contrast to DCIR2+ cDC2 which mediate immunogenicity. Targeting DC using autoantigen peptide-antibody fusion proteins has been a well explored methodology for inducing toler… Show more
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