Targeted chemo-sonodynamic therapy treatment of breast tumours using ultrasound responsive microbubbles loaded with paclitaxel, doxorubicin and Rose Bengal

Logan, Keiran; Foglietta, Federica; Nesbitt, Heather; Sheng, Yu; McKaig, Thomas; Kamila, Sukanta; Gao, Jinhui; Nomikou, Nikolitsa; Callan, Bridgeen; McHale, Anthony P.; Callan, John F.

doi:10.1016/j.ejpb.2019.04.003

Cited by 55 publications

(44 citation statements)

References 24 publications

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“…In numerous pilot studies, microbubbles have been identified as a mechanism for encapsulating drugs, such as DOX and paclitaxel, for drug delivery [14,15,16,17]. The carried drug within bubbles could be triggered release upon US sonication, achieving local drug delivery while decreasing the drug exposure in blood circulation [18,19,20,21,22]. Additionally, bubbles exhibit a bi-functional characteristic that merges ultrasonic diagnosis with therapy.…”

Section: Introductionmentioning

confidence: 99%

Concurrent Osteosarcoma Theranostic Strategy Using Contrast-Enhanced Ultrasound and Drug-Loaded Bubbles

Kuo

Wang

et al. 2019

Pharmaceutics

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Osteosarcoma (OS) is the most common bone tumor in children and teenagers. The multidrug resistant property of OS produces a major obstacle to chemotherapy, since the effective drug dose cannot be achieved via conventional drug delivery routes without serious systemic cytotoxicity. Microbubbles in conjunction with ultrasound (US) has recently been shown to spatially and temporally permeabilize the cellular membrane, promoting drug penetration into tumors. Here, we investigated whether drug (doxorubicin, DOX)-loaded bubbles (DOX-bubbles) can serve as drug-loaded carriers in combination with US in order to facilitate tumor drug delivery. The proposed bubbles have a high payload capacity (efficiency of 69.4 ± 9.1%, payload of 1.4 mg/mL) for DOX. In vitro data revealed that when used in combination with US (1-MHz), these DOX-bubbles facilitate DOX entering into tumor cells. In tumor-bearing animals, DOX-bubbles + US could provide 3.7-fold suppression of tumor growth compared with the group without insonation (1.8 ± 0.9 cm3 vs. 8.5 ± 2.2 cm3) because of the acceleration of DOX-induced tumor necrosis. In the meantime, the tumor perfusion and volume can be monitored by DOX-bubbles with contrast-enhanced ultrasound imaging. Our data provide useful information in support of translating the use of theranostic US-responsive bubbles for regulated tumor drug delivery into clinical use.

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Section: Introductionmentioning

confidence: 99%

Concurrent Osteosarcoma Theranostic Strategy Using Contrast-Enhanced Ultrasound and Drug-Loaded Bubbles

Kuo

Wang

et al. 2019

Pharmaceutics

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“…Likewise, they have an extra advantage of allowing imaging of the tumour by ultrasound techniques [49]. A successful trial for nanobubbles being used as carriers for doxorubicin as an anticancer drug on the basis of in vitro and in vivo studies was reported by Rapaport et al [50]. They used an ultrasound external source to cause disturbances for the aggregated nanobubbles that in turn started the doxorubicin release.…”

Section: Nanobubblesmentioning

confidence: 99%

Nanomaterials for Biomedical Applications: Production, Characterisations, Recent Trends and Difficulties

et al. 2021

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Designing of nanomaterials has now become a top-priority research goal with a view to developing specific applications in the biomedical fields. In fact, the recent trends in the literature show that there is a lack of in-depth reviews that specifically highlight the current knowledge based on the design and production of nanomaterials. Considerations of size, shape, surface charge and microstructures are important factors in this regard as they affect the performance of nanoparticles (NPs). These parameters are also found to be dependent on their synthesis methods. The characterisation techniques that have been used for the investigation of these nanomaterials are relatively different in their concepts, sample preparation methods and obtained results. Consequently, this review article aims to carry out an in-depth discussion on the recent trends on nanomaterials for biomedical engineering, with a particular emphasis on the choices of the nanomaterials, preparation methods/instruments and characterisations techniques used for designing of nanomaterials. Key applications of these nanomaterials, such as tissue regeneration, medication delivery and wound healing, are also discussed briefly. Covering this knowledge gap will result in a better understanding of the role of nanomaterial design and subsequent larger-scale applications in terms of both its potential and difficulties.

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“…US contrast agents are also well‐suited for a variety of therapeutic applications including drug‐delivery for anticancer therapy, atherosclerosis therapy, thrombolytic therapy, gene therapy and so on (Logan et al, ; McEwan et al, ; Zhou et al, ). Nevertheless, this review mainly summarizes the therapeutic applications of MBs in cancer‐related applications.…”

Section: Therapeutic Applications Of Microbubblesmentioning

confidence: 99%

Enhancing cancer therapeutic efficacy through ultrasound‐mediated micro‐to‐nano conversion

Hameed

Zhang

Bhattarai

et al. 2019

WIREs Nanomed Nanobiotechnol

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Over the last century, significant progress has been made towards the development of microbubbles (MBs) as a contrast agent for imaging and as a carrier for the delivery of therapeutic moieties. The unparalleled ability of MBs to respond to ultrasound (US) render them advantageous for molecular imaging, and US‐responsive targeted delivery. However, the use of MBs has broadened far beyond the imaging contrast agent or drug delivery system alone. Notably, there has been an enormous surge in the design and fabrication of multimodal MBs for cancer therapy. Furthermore, MBs in the presence of the US has unique ability to convert itself from the micro to nanoscale, which offers diagnostic and therapeutic ability in both dimensions. In this review, we summarize the design considerations of MBs, with particular emphasize on their size and composition. In addition, different MBs formulations are discussed in the context of their current progress as an imaging contrast agent and a vehicle for drug/gene delivery. We further highlight recent advancements in the micro‐to‐nano conversion of MBs and their potential application for cancer theranostics. This article is characterized under: Therapeutic Approaches and Drug Discovery > Nanomedicine for Oncologic Disease Therapeutic Approaches and Drug Discovery > Emerging Technologies

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Targeted chemo-sonodynamic therapy treatment of breast tumours using ultrasound responsive microbubbles loaded with paclitaxel, doxorubicin and Rose Bengal

Cited by 55 publications

References 24 publications

Concurrent Osteosarcoma Theranostic Strategy Using Contrast-Enhanced Ultrasound and Drug-Loaded Bubbles

Concurrent Osteosarcoma Theranostic Strategy Using Contrast-Enhanced Ultrasound and Drug-Loaded Bubbles

Nanomaterials for Biomedical Applications: Production, Characterisations, Recent Trends and Difficulties

Enhancing cancer therapeutic efficacy through ultrasound‐mediated micro‐to‐nano conversion

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