Targeted cell delivery for articular cartilage regeneration and osteoarthritis treatment

Nasiri, Nahid; Hosseini, Samaneh; Alini, Mauro; Khademhosseini, Ali; Eslaminejad, Mohamadreza Baghaban

doi:10.1016/j.drudis.2019.07.010

Cited by 35 publications

(23 citation statements)

References 90 publications

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“…Osteoarthritis is another age-related joint disease in which cell delivery therapy has progressed. The cartilage is composed of specialized cells known as chondrocytes, which produce a large number of collagenous extracellular matrices, and osteoarthritis is a degenerative cartilage disorder [121]. Adipose-derived SCs and MSCs delivered with the ECM were investigated to secrete the newly synthesized ECM, which can restore the ECMproducing function of cartilage [104,122].…”

Section: Ecm-based Materials As Cell Delivery Carriersmentioning

confidence: 99%

Employing Extracellular Matrix-Based Tissue Engineering Strategies for Age-Dependent Tissue Degenerations

Hwang

Jang

2021

IJMS

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Tissues and organs are not composed of solely cellular components; instead, they converge with an extracellular matrix (ECM). The composition and function of the ECM differ depending on tissue types. The ECM provides a microenvironment that is essential for cellular functionality and regulation. However, during aging, the ECM undergoes significant changes along with the cellular components. The ECM constituents are over- or down-expressed, degraded, and deformed in senescence cells. ECM aging contributes to tissue dysfunction and failure of stem cell maintenance. Aging is the primary risk factor for prevalent diseases, and ECM aging is directly or indirectly correlated to it. Hence, rejuvenation strategies are necessitated to treat various age-associated symptoms. Recent rejuvenation strategies focus on the ECM as the basic biomaterial for regenerative therapies, such as tissue engineering. Modified and decellularized ECMs can be used to substitute aged ECMs and cell niches for culturing engineered tissues. Various tissue engineering approaches, including three-dimensional bioprinting, enable cell delivery and the fabrication of transplantable engineered tissues by employing ECM-based biomaterials.

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Section: Ecm-based Materials As Cell Delivery Carriersmentioning

confidence: 99%

Employing Extracellular Matrix-Based Tissue Engineering Strategies for Age-Dependent Tissue Degenerations

Hwang

Jang

2021

IJMS

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“…Large amount of filtration is experienced by intraarticular fluid through the capillaries and then enter the joint cavity and also undergoes drainage into lymphatic space from synovial cavity. This limits the intra-articular injection due to the reduction of the lifespan of the drug in the cartilage (Nasiri et. al., 2019).…”

Section: Limitations Associated With Conventional Based Drug Delivery To Skeletal Systemmentioning

confidence: 99%

Nanotechnology: A New Hope for the Cure of Osteoarthritis, Osteoporosis and Rheumatoid Arthritis

Qaiser

Ibrahim

Mazhar

et al. 2020

GPSR

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Bone and cartilage diseases especially osteoporosis, osteoarthritis and rheumatoid arthritis are rapidly prevailing both in men and women particularly due to increase in life expectancies. Different treatments are being proposed using conventional drugs and their modifications. But the side effects associated with such drugs and difficulty in treatment strategies due to multifactorial nature of such diseases and difficulty in drug delivery led the researchers towards the development of more advanced technologies for the treatment purpose. Nanotechnology is a promising strategy for treating such diseases that suppresses the progression of such diseases providing causal treatment. In this review, we will summarize the recent nano-based targeted and non-targeted delivery systems using various types of nanoparticles, nanogels, nanocomplexes, nanocarriers, hydrogels etc. for the efficient delivery of drugs and other therapeutic agents like mRNA, genes, insulin-growth factors etc. Moreover, role of nanoparticles for bone and cartilage repair in tissue engineering will also be discussed.

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“…This can result in joint pain, swelling, dysfunction, and eventually lead to osteoarthritis (OA). 3,4 In the past two decades, OA has been the most common form of arthritis accounting for approximately 300 million patients worldwide and undoubtedly has been considered as one of the most significant health problems that also pose a substantial financial burden on the public health system, and the patients themselves. 5 Currently, conservative treatments, including pharmacological and non-pharmacological therapies, are commonly applied to improve joint pain, reduce stiffness and improve physical function in patients with OA.…”

Section: Introductionmentioning

confidence: 99%

<p>Growth Factor and Its Polymer Scaffold-Based Delivery System for Cartilage Tissue Engineering</p>

Chen¹,

Liu²,

Guan³

et al. 2020

IJN

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The development of biomaterials, stem cells and bioactive factors has led to cartilage tissue engineering becoming a promising tactic to repair cartilage defects. Various polymer three-dimensional scaffolds that provide an extracellular matrix (ECM) mimicking environment play an important role in promoting cartilage regeneration. In addition, numerous growth factors have been found in the regenerative process. However, it has been elucidated that the uncontrolled delivery of these factors cannot fully exert regenerative potential and can also elicit undesired side effects. Considering the complexity of the ECM, neither scaffolds nor growth factors can independently obtain successful outcomes in cartilage tissue engineering. Therefore, collectively, an appropriate combination of growth factors and scaffolds have great potential to promote cartilage repair effectively; this approach has become an area of considerable interest in recent investigations. Of late, an increasing trend was observed in cartilage tissue engineering towards this combination to develop a controlled delivery system that provides adequate physical support for neo-cartilage formation and also enables spatiotemporally delivery of growth factors to precisely and fully exert their chondrogenic potential. This review will discuss the role of polymer scaffolds and various growth factors involved in cartilage tissue engineering. Several growth factor delivery strategies based on the polymer scaffolds will also be discussed, with examples from recent studies highlighting the importance of spatiotemporal strategies for the controlled delivery of single or multiple growth factors in cartilage tissue engineering applications.

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Targeted cell delivery for articular cartilage regeneration and osteoarthritis treatment

Cited by 35 publications

References 90 publications

Employing Extracellular Matrix-Based Tissue Engineering Strategies for Age-Dependent Tissue Degenerations

Employing Extracellular Matrix-Based Tissue Engineering Strategies for Age-Dependent Tissue Degenerations

Nanotechnology: A New Hope for the Cure of Osteoarthritis, Osteoporosis and Rheumatoid Arthritis

<p>Growth Factor and Its Polymer Scaffold-Based Delivery System for Cartilage Tissue Engineering</p>

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