Target-Responsive “Sweet” Hydrogel with Glucometer Readout for Portable and Quantitative Detection of Non-Glucose Targets

Yan, Ling; Zhu, Zhi; Zou, Yu; Huang, Yishun; Liu, Dewen; Jia, Shasha; Xu, Defeng; Wu, Min; Zhou, Yu; Zhou, Shuang; Yang, Chaoyong

doi:10.1021/ja3114714

Cited by 301 publications

(223 citation statements)

References 44 publications

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“…This method was further extended and, by combining with a personal glucose meter, a quantitative detection system of non-glucose targets was developed. 326,354 By entrapping gold nanoparticles in aptamer-based DNA hydrogels, proteins were also detected with a very high sensitivity. 355 When the target protein was recognized by the aptamer in the gel, the gel was broken down and the gold nanoparticles were released to the solutions.…”

Section: Sensing In Vivo and In Vitromentioning

confidence: 99%

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Chemistry Can Make Strict and Fuzzy Controls for Bio-Systems: DNA Nanoarchitectonics and Cell-Macromolecular Nanoarchitectonics

Komiyama

Yoshimoto

Sisido

et al. 2017

Bulletin of the Chemical Society of Japan

266

128

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In this review, we introduce two kinds of bio-related nanoarchitectonics, DNA nanoarchitectonics and cellmacromolecular nanoarchitectonics, both of which are basically controlled by chemical strategies. The former DNA-based approach would represent the precise nature of the nanoarchitectonics based on the strict or "digital" molecular recognition between nucleic bases. This part includes functionalization of single DNAs by chemical means, modification of the main-chain or side-chain bases to achieve stronger DNA binding, DNA aptamers and DNAzymes. It also includes programmable assemblies of DNAs (DNA Origami) and their applications for delivery of drugs to target sites in vivo, sensing in vivo, and selective labeling of biomaterials in cells and in animals. In contrast to the digital molecular recognition between nucleic bases, cell membrane assemblies and their interaction with macromolecules are achieved through rather generic and "analog" interactions such as hydrophobic effects and electrostatic forces. This cell-macromolecular nanoarchitectonics is discussed in the latter part of this review. This part includes bottom-up and top-down approaches for constructing highly organized cell-architectures with macromolecules, for regulating cell adhesion pattern and their functions in twodimension, for generating three-dimensional cell architectures on micro-patterned surfaces, and for building synthetic/natural macromolecular modified hybrid biointerfaces.

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Section: Sensing In Vivo and In Vitromentioning

confidence: 99%

“…This system was easily extended to colorimetric 325 and quantitative analysis. 326 By combining two aptamers, sophisticated systems showing "AND" or "OR" logic-gate were also developed. 327 In "AND" logic-gate, the gel-sol transition occurred only when both of the guest molecules towards the two aptamers simultaneously existed in the solutions.…”

mentioning

confidence: 99%

Chemistry Can Make Strict and Fuzzy Controls for Bio-Systems: DNA Nanoarchitectonics and Cell-Macromolecular Nanoarchitectonics

Komiyama

Yoshimoto

Sisido

et al. 2017

Bulletin of the Chemical Society of Japan

266

128

View full text Add to dashboard Cite

show abstract

“…Recently, the DNA sensors, which were attached with a general GM were developed for the efficient detection of several targets, e.g., protein biomarkers [89,90] and recreational drugs [91,92].…”

Section: Glucose Biosensorsmentioning

confidence: 99%

Recent Advances and Applications of Biosensors in Novel Technology

Rajpoot¹

2017

Biosens J

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In recent time, several novel biosensors such as enzyme based, immunosensors, tissue-based, DNA biosensors, piezoelectric, and thermal biosensors have been explored with high sensitivity by many research groups. These biosensors exhibit many essential benefits, including operational simplicity, remarkable sensitivity, low-cost instrumentation, the potential of automation, inherent miniaturization. They have offered elegant paths for the detection of even trace amounts of analytical agents of biological significance existing from macromolecules (e.g., disease biomarkers and antigens) and small molecules (e.g., natural toxins and haptens) to cells, viruses, and bacteria. Many electrochemical techniques viz., amperometry and voltammetry, photoelectrochemistry, electrochemiluminescence, impedance, piezoelectricity, potentiometry, alternating current electrohydrodynamics, and field-effect transistor have been utilized in the development of immunoassays to attain high sensitivity for electrochemical signal transduction. Recent developments in biological methods and instrumentation after using fluorescence tag to various nanocarriers such as nanoparticles, nanowires, nanotubes, etc. have improved the sensitivity of biosensors. Utilization of nucleotides/aptamers, affibodies, molecule imprinted polymers, and peptide arrays offer great tools to prepare advanced biosensors. Merging of nanotechnology with biosensor systems enhanced the diagnostic capability. This review gives an outline of the advances in biosensors technology relating biomedical sciences.

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“…Using the same systems, Yan et al fabricated a gel with entrapped glucoamylase using aptamers as crosslinker [56]. Glucoamylase is also an enzyme that can break down amylose.…”

Section: Sensing Based On Gel-sol Transitionmentioning

confidence: 99%