2014
DOI: 10.1021/ac500251t
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Abstract: Because of the short size and low abundance of microRNAs, it is challenging to develop fast, inexpensive, and simple biosensors to detect them. In this work, we have demonstrated a new generation (the third generation) of E-DNA sensor for the sensitive and specific detection of microRNAs. Our third generation of E-DNA sensor can sensitively detect microRNA target (microRNA-141) as low as 1 fM. The excellent specificity has been demonstrated by its differential ability to the highly similar microRNA analogues. … Show more

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Cited by 129 publications
(79 citation statements)
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“…As a universal biosensing platform, we have tested this protocol to detect DNA, microRNA (mir-21, mir-141 and others), proteins (antigens such as prostate-specific antigen (PSA), thrombin and others) and small molecules (cocaine) [19][20][21][22][23][24][25][26] . Furthermore, we have used our detection platform to detect target molecules in complicated biological fluids such as cell lysates, tissue extracts and human serum, and we observed excellent sensing performance.…”
Section: Applications Of the Methodsmentioning
confidence: 99%
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“…As a universal biosensing platform, we have tested this protocol to detect DNA, microRNA (mir-21, mir-141 and others), proteins (antigens such as prostate-specific antigen (PSA), thrombin and others) and small molecules (cocaine) [19][20][21][22][23][24][25][26] . Furthermore, we have used our detection platform to detect target molecules in complicated biological fluids such as cell lysates, tissue extracts and human serum, and we observed excellent sensing performance.…”
Section: Applications Of the Methodsmentioning
confidence: 99%
“…We have demonstrated that one can finely tune the kinetics and thermodynamics of interfacial biomolecular recognition by varying the size of TDNs. Under optimal conditions, this TDN-based biosensing platform can greatly increase target accessibility and improve the sensitivity by several orders of magnitude for various types of molecular targets (DNA, RNA, proteins and small molecules) and even whole cells [19][20][21][22][23][24][25][26] .…”
Section: Introductionmentioning
confidence: 99%
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“…TSP is a tetrahedral DNA nano structure with a thiol at each bottom vertex and a pendent capture probe on its top vertex. Excellent TSP-related electrochemical biosensors for cocaine (Wen et al, 2011) and microRNA (Lin et al, 2014) have been developed, showing TSP's advantages of stable and ordered self-assembling and resistance of unspecific absorbance (Wen et al, 2013).…”
Section: Introductionmentioning
confidence: 99%