volume 6, issue 5, P390-398 2014
DOI: 10.18632/aging.100665
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Sahar Emran, Mingyao Yang, Xiaoli He, Jelle Zandveld, Matthew D. W. Piper

Abstract: Dietary restriction (DR), defined as a moderate reduction in food intake short of malnutrition, has been shown to extend healthy lifespan in a diverse range of organisms, from yeast to primates. Reduced signalling through the insulin/IGF-like (IIS) and Target of Rapamycin (TOR) signalling pathways also extend lifespan. In Drosophila melanogaster the lifespan benefits of DR can be reproduced by modulating only the essential amino acids in yeast based food. Here, we show that pharmacological downregulation of TO…

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