Target-controlled infusion of propofol combined with variable rate infusion of remifentanil for anaesthesia of a dog with patent ductus arteriosus

Musk, Gabrielle C.; Flaherty, Derek

doi:10.1111/j.1467-2995.2006.00332.x

Cited by 23 publications

(28 citation statements)

References 31 publications

(60 reference statements)

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“…Although the dose of propofol administered was higher than in some studies, mean SAP, MAP and DAP after propofol administration were similar to those reported in studies in which lower propofol doses were administered. It was confirmed in previous studies that hypotension is less pronounced when propofol is administered slowly 5,8,25 . The remifentanil and fentanyl infusion rates used in our study were extrapolated from published data 7,8,14 .…”

Section: Discussionsupporting

confidence: 72%

“…There are also studies, in which propofol was administered slowly for induction and no adverse effects associated with respiratory depression were reported 7,8,22 . In this study, none of the animals exhibited apnea after induction with propofol, which may have resulted from slow IV administration and the discontinuation of injections after a satisfactory depth of anesthesia was achieved for intubation 5,6,9,21 . Propofol is a negative inotrope and reduces systemic vascular resistance, causing dose-dependent hypotension.…”

Section: Discussionmentioning

confidence: 99%

“…Thus, it may be combined with some opioids like remifentanil or fentanyl. In this study, both drugs are considered as ideal analgesics for continuous infusion when combined with propofol 2,5,7,17,22,23 .…”

Section: Discussionmentioning

confidence: 99%

“…Its ultra-short action, rapid control of the depth of anesthesia, and lack of dependence on organ functions for breakdown and clearance make remifentanil more advantageous than fentanyl. Remifentanil does not accumulate in the body even after prolonged infusion, and its terminal half-life has been reported to be less than 6 minutes 5,12,13 . These properties make remifentanil ideal as part of a total IV anesthesia technique 8,14,15 .…”

Section: Introductionmentioning

confidence: 99%

“…Minimal accumulation on repeated or constant administration makes propofol suitable for both the induction and maintenance of anesthesia [5][6][7] . Total intravenous (IV) anesthesia with propofol has been widely investigated in dogs, however, due to the lack of analgesic properties this drug is considered inadequate to provide anesthesia during surgery [5][6][7][8][9] .…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Comparison of Propofol-Remifentanil and Propofol-Fentanyl Anesthesia During Ovariohysterectomy in Dogs

Kürüm¹,

Pekcan²,

Kalender³

et al. 2013

Kafkas Univ Vet Fak Derg

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The aim of the study was to evaluate the cardiorespiratory and clinical effects of propofol and remifentanil anesthesia compared to propofol and fentanyl anesthesia during ovariohysterectomy in dogs. Sixteen healthy dogs were randomly assigned to two groups. After premedication with atropine, anesthesia was induced with propofol and maintained with the infusion of propofol at a dose of 0.5 mg/kg/min. Once stable anesthesia was achieved, 1 µg/kg remifentanil or 2 µg/kg fentanyl was administered intravenously, and infusion was begun at a dose of 0.6 µg/kg/min and 0.5 µg/kg/min, respectively. Cardiorespiratory variables were recorded after propofol administration combined with remifentanil or fentanyl at 10-min intervals, and the quality of anesthesia, return of spontaneous ventilation, head lift and sternal position were also recorded. Apnea was observed after remifentanil and fentanyl administration in all dogs. Heart rate, systolic and mean arterial blood pressures tended to decrease rapidly after remifentanil and fentanyl administration, and during the first 20 min, in both groups. Although the difference between times was significant, the difference between groups was statistically insignificant. Recovery periods were longer in the fentanyl group than in the remifentanil group. The administration of propofol with remifentanil or fentanyl provides a stable haemodynamic state and depth of anesthesia with a constant infusion, and remifentanil could be preferred to fentanyl when aiming a rapid recovery period. Propofol, Remifentanil, Fentanyl, Anesthesia, Cardiorespiratory, Recovery, Dog Köpeklerde Ovariohisterektomi Operasyonunda Propofol-Remifentanil ve Propofol-Fentanil Anestezisinin Karşılaştırılması Keywords: ÖzetBu çalışmanın amacı köpeklerde ovariohysterektomi operasyonunda propofol-remifentanil ile propofol-fentanil anestezisinin etkinliğini ve kardiyorespiratorik etkilerini karşılaştırmaktır. Bu amaçla 16 adet yetişkin, dişi köpek rastgele iki gruba (n=8) ayrıldı. Anesteziye atropin ile premedikasyon yapılarak başlandıktan sonra propofol ile indüksiyon yapıldı ve 0.5 mg/kg/dk dozunda propofol infüzyonuna başlandı. Stabil anesteziden sonra ilk gruba 1 µg/kg remifentanil, ikinci gruba 2 µg/kg fentanyl bolus olarak uygulandı. Remifentanil ve fentanil infüzyonu sırasıyla 0.6 µg/kg/dk ve 0.5 µg/kg/dk dozunda devam edildi. Kardiyovasküler değişiklikler propofol sonrası, remifentanil veya fentanil sonrası ve operasyon süresince 10 dakika aralıklarla kaydedildi. Anestezinin derinliği, spontan ventilasyonun başlama, kafayı kaldırma ve sternal pozisyona gelme zamanları kaydedildi. Tüm olgularda remifentanil ve fentanil uygulamasından sonra apnea oluşumu gözlendi. Her iki grupta da kalp atım hızı, sistolik (SAP) ve ortalama arteriyel basınç (MAP) değerlerinin remifentanil ve fentanil uygulanmasından sonra hızla düştüğü ve ilk 20 dakikada düşmeye devam ettiği görüldü. Bu değerlerde zaman içindeki farklılıklar istatistiksel olarak anlamlı olarak kaydedilirken, gruplar arasında istatistiksel açıdan anlamlı olmadığı ...

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