2014
DOI: 10.18632/aging.100701
View full text |Buy / Rent full text
|
Sign up to set email alerts
|

Abstract: TAp73, a member of the p53 family, has been traditionally considered a tumor suppressor gene, but a recent report has claimed that it can promote cellular proliferation. This assumption is based on biochemical evidence of activation of anabolic metabolism, with enhanced pentose phosphate shunt (PPP) and nucleotide biosynthesis. Here, while we confirm that TAp73 expression enhances anabolism, we also substantiate its role in inhibiting proliferation and promoting cell death. Hence, we would like to propose an a… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1

Citation Types

3
23
0

Year Published

2017
2017
2019
2019

Publication Types

Select...
2

Relationship

1
1

Authors

Journals

citations
Cited by 17 publications
(26 citation statements)
references
References 96 publications
(72 reference statements)
3
23
0
Order By: Relevance
“…In line with these findings, the effect of TP73‐AS1 kd on cell cycle was variable in TP53 ‐WT medulloblastoma cells (Supporting Information Fig. S1B) . Finally, we compared ROS levels between TP73‐AS1 kd and control cells and found that ROS levels were increased in one TP53 ‐WT cell lines, MED8A and one p53‐mutant cell lines, DAOY, but not in the other TP53 ‐WT cell line, ONS76, or p53‐mutant UW228.2 cell line (Fig.…”
Section: Resultsmentioning
confidence: 99%
See 2 more Smart Citations
“…In line with these findings, the effect of TP73‐AS1 kd on cell cycle was variable in TP53 ‐WT medulloblastoma cells (Supporting Information Fig. S1B) . Finally, we compared ROS levels between TP73‐AS1 kd and control cells and found that ROS levels were increased in one TP53 ‐WT cell lines, MED8A and one p53‐mutant cell lines, DAOY, but not in the other TP53 ‐WT cell line, ONS76, or p53‐mutant UW228.2 cell line (Fig.…”
Section: Resultsmentioning
confidence: 99%
“…S1B). 45 Finally, we compared ROS levels between TP73-AS1 kd and control cells and found that ROS levels were increased in one TP53-WT cell lines, MED8A and one p53-mutant cell lines, DAOY, but not in the other TP53-WT cell line, ONS76, or p53-mutant UW228.2 cell line (Fig. 1c).…”
Section: Tp73-as1 Support Medulloblastoma Tumor Cell Viabilitymentioning
confidence: 96%
See 1 more Smart Citation
“…Recently we have also shown that p73 regulates cellular metabolism [37,15,18]. With regard to CNS, our previous data indicate that cortical neurons isolated from TAp73-/-mice appeared to have reduced levels of GABA, while levels of the inhibitory neurotransmitter glycine were reduced in ΔNp73-/-cells [41].…”
Section: Resultsmentioning
confidence: 99%
“…In addition, TAp73 controls the expression of miR-34a, suggesting that microRNAs [36,26] also participate in the multifunctional role of p73 in neurons, such as differentiation [26]. Growing findings indicate that p73 proteins also regulate cellular metabolism [37][38][39][40], and we have recently shown that during neuronal differentiation, TAp73 promotes the expression of glutaminase 2 (GLS2), an enzyme that deaminates glutamine to produce glutamate, the most common excitatory neurotransmitter [41]. This latter discovery indicates that p73-mediated regulation of metabolism is an additional player in the regulation of neuronal function.…”
Section: Introductionmentioning
confidence: 99%