2019
DOI: 10.1159/000495755
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Abstract: To investigate the effect of Tanshinone IIA (TSA) on viral myocarditis (VMC). VMC animal model was established using BALB/c mice by intraperitoneally injecting Coxsackie virus B3 (CVB3). The mice were randomly divided into control group, model group, and TSA group. We detected the survival rate, the heart weight to body weight (HW/BW) ratio and hemodynamic and cardiac function parameters. The pathological features of VMC were measured through H&E staining. The expression of serum enzyme, inflammatory cytokines… Show more

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Cited by 3 publications
(2 citation statements)
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“…In fact, these terpenes exhibited a significant inhibitory effect on SARS-CoV cysteine proteases (3CL pro and PL pro ) and provide good scaffolds for further optimization and drug development against CoV infection. Tanshinone IIA also inhibited Tat-induced Human immunodeficiency virus-1 [ 40 ] and attenuated the viral myocarditis caused by coxsackievirus B3 [ 41 ], whereas cryptotanshinone showed anti-influenza A virus activity [ 42 ].…”
Section: Resultsmentioning
confidence: 99%
“…In fact, these terpenes exhibited a significant inhibitory effect on SARS-CoV cysteine proteases (3CL pro and PL pro ) and provide good scaffolds for further optimization and drug development against CoV infection. Tanshinone IIA also inhibited Tat-induced Human immunodeficiency virus-1 [ 40 ] and attenuated the viral myocarditis caused by coxsackievirus B3 [ 41 ], whereas cryptotanshinone showed anti-influenza A virus activity [ 42 ].…”
Section: Resultsmentioning
confidence: 99%
“…Therefore, elucidating the Th1/Th2 response might help to understand the activity of VMC. Based on these results, several drugs, such as atorvastatin, tanshinone IIA, apigenin, and cyclooxygenase-2 inhibitors, have been shown to have protective effects on rat model of myocarditis by regulating Th1/Th2 balance ( 79 82 ). However, the above drugs can promote Th2 response, which may aggravate the progression of VMC to DMC or HF.…”
Section: Th1/th2 Responsesmentioning
confidence: 99%