Tannic acid-induced interfacial ligand-to-metal charge transfer and the phase transformation of Fe3O4 nanoparticles for the photothermal bacteria destruction

Chang, Te-Wei; Ko, Han Seo; Huang, Wei-Shiang; Chiu, Yi‐Chun; Yang, Li‐Xing; Chia, Zi-Chun; Chin, Yu‐Cheng; Chen, Ya-Jyun; Tsai, Yi‐Tseng; Hsu, Che-Wei; Chang, Chia-Ching; Tsai, Pei‐Jane; Huang, Chih‐Chia

doi:10.1016/j.cej.2021.131237

Cited by 36 publications

(25 citation statements)

References 78 publications

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“…The time constant of suspension cooling

= 318 s was used for calculation of photothermal conversion efficiency coefficient (η) ( Figure 3 e,f). Fe-Au@PAA particles show η = 38%; thus, their efficiency exceeds those reported for gold nanoparticles (10.2%) [ 38 ], gold nanoshells (13%) [ 34 ], other iron-oxide nanoparticles with modified surface (13.1–35.7%) [ 39 ], and is comparable to another Fe-Au core-shell nanocomposites (42.6%) [ 17 ] evaluated under NIR irradiation.…”

Section: Resultsmentioning

confidence: 82%

Laser Synthesized Core-Satellite Fe-Au Nanoparticles for Multimodal In Vivo Imaging and In Vitro Photothermal Therapy

et al. 2022

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Hybrid multimodal nanoparticles, applicable simultaneously to the noninvasive imaging and therapeutic treatment, are highly demanded for clinical use. Here, Fe-Au core-satellite nanoparticles prepared by the method of pulsed laser ablation in liquids were evaluated as dual magnetic resonance imaging (MRI) and computed tomography (CT) contrast agents and as sensitizers for laser-induced hyperthermia of cancer cells. The biocompatibility of Fe-Au nanoparticles was improved by coating with polyacrylic acid, which provided excellent colloidal stability of nanoparticles with highly negative ζ-potential in water (−38 ± 7 mV) and retained hydrodynamic size (88 ± 20 nm) in a physiological environment. The ferromagnetic iron cores offered great contrast in MRI images with r2 = 11.8 ± 0.8 mM−1 s−1 (at 1 T), while Au satellites showed X-ray attenuation in CT. The intravenous injection of nanoparticles enabled clear tumor border visualization in mice. Plasmonic peak in the Fe-Au hybrids had a tail in the near-infrared region (NIR), allowing them to cause hyperthermia under 808 nm laser exposure. Under NIR irradiation Fe-Au particles provided 24.1 °C/W heating and an IC50 value below 32 µg/mL for three different cancer cell lines. Taken together, these results show that laser synthesized Fe-Au core-satellite nanoparticles are excellent theranostic agents with multimodal imaging and photothermal capabilities.

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“…The time constant of suspension cooling

Section: Resultsmentioning

confidence: 82%

Laser Synthesized Core-Satellite Fe-Au Nanoparticles for Multimodal In Vivo Imaging and In Vitro Photothermal Therapy

et al. 2022

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“…As shown in Fig. 1 e, the reflection peaks at 35.8°, 43.2°, 57.6°, and 63.2° in the XRD pattern could be assigned to the (311), (400), (511), and (440) planes, respectively, of fcc-structure Fe 3 O 4 [ 40 , 41 ]. A strong peak was observed at 670 cm −1 in the Raman spectra (Additional file 1 : Fig.…”

Section: Resultsmentioning

confidence: 99%

“…A strong peak was observed at 670 cm −1 in the Raman spectra (Additional file 1 : Fig. S2) and was attributed to the A 1g mode [ 40 , 41 ] of Fe 3 O 4 . The lack of the characteristic peaks of Chl/Fe may be due to its low Raman scattering cross-section.…”

Section: Resultsmentioning

confidence: 99%

“…2 a, the binding energies of Fe 2p 3/2 and 2p 1/2 at 710.8 eV and 724.2 eV were determined. The central peak at 529.8 eV was assigned to the O 1s orbital in the crystal structure of the Fe 3 O 4 material [ 40 ], while the additional O 1s peaks at 531.0 and 532.1 eV were related to the Chl capping molecule of Fe 3 O 4 @Chl/Fe CNPs (Fig. 2 b) [ 42 ].…”

Section: Resultsmentioning

confidence: 99%

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Iron oxide@chlorophyll clustered nanoparticles eliminate bladder cancer by photodynamic immunotherapy-initiated ferroptosis and immunostimulation

et al. 2022

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The escape of bladder cancer from immunosurveillance causes monotherapy to exhibit poor efficacy; therefore, designing a multifunctional nanoparticle that boosts programmed cell death and immunoactivation has potential as a treatment strategy. Herein, we developed a facile one-pot coprecipitation reaction to fabricate cluster-structured nanoparticles (CNPs) assembled from Fe3O4 and iron chlorophyll (Chl/Fe) photosensitizers. This nanoassembled CNP, as a multifunctional theranostic agent, could perform red-NIR fluorescence and change the redox balance by the photoinduction of reactive oxygen species (ROS) and attenuate iron-mediated lipid peroxidation by the induction of a Fenton-like reaction. The intravesical instillation of Fe3O4@Chl/Fe CNPs modified with 4-carboxyphenylboronic acid (CPBA) may target the BC wall through glycoproteins in the BC cavity, allowing local killing of cancer cells by photodynamic therapy (PDT)-induced singlet oxygen and causing chemodynamic therapy (CDT)-mediated ferroptosis. An interesting possibility is reprogramming of the tumor microenvironment from immunosuppressive to immunostimulatory after PDT-CDT treatment, which was demonstrated by the reduction of PD-L1 (lower “off” signal to the effector immune cells), IDO-1, TGF-β, and M2-like macrophages and the induction of CD8+ T cells on BC sections. Moreover, the intravesical instillation of Fe3O4@Chl/Fe CNPs may enhance the large-area distribution on the BC wall, improving antitumor efficacy and increasing survival rates from 0 to 91.7%. Our theranostic CNPs not only demonstrated combined PDT-CDT-induced cytotoxicity, ROS production, and ferroptosis to facilitate treatment efficacy but also opened up new horizons for eliminating the immunosuppressive effect by simultaneous PDT-CDT.

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“…[10][11][12] Although the MNP is designed as a carrier of the drugs and exhibits excellent biocompatibilities and low toxicities, [13][14][15] the effects of the MNP itself should not be ignored. However, currently, much effort is devoted to addressing several important issues such as MNP fabrication, functionalized modification, drug conjugation, and delivery selectivity, [16][17][18][19] and the focus on elucidating the molecular pathogenesis of MNP in cancer cells is lacking.…”

Section: Introductionmentioning

confidence: 99%

Systematic Identification of Genomic Markers for Guiding Iron Oxide Nanoparticles in Cervical Cancer Based on Translational Bioinformatics

Zhou¹,

Tian²,

Sun³

et al. 2022

IJN

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Magnetic iron oxide nanoparticle (MNP) drug delivery system is a novel promising therapeutic option for cancer treatment. Material issues such as fabrication and functionalized modification have been investigated; however, pharmacologic mechanisms of bare MNPs inside cancer cells remain obscure. This study aimed to explore a systems pharmacology approach to understand the reaction of the whole cell to MNPs and suggest drug selection in MNP delivery systems to exert synergetic or additive anti-cancer effects. Methods: HeLa and SiHa cell lines were used to estimate the properties of bare MNPs in cervical cancer through 3-[4,5-dimethylthiazol-2-yl]-2,5 diphenyl tetrazolium bromide (MTT) and enzyme activity assays and cellular fluorescence imaging. A systems pharmacology approach was utilized by combining bioinformatics data mining with clinical data analysis and without a predefined hypothesis. Key genes of the MNP onco-pharmacologic mechanism in cervical cancer were identified and further validated through transcriptome analysis with quantitative reverse transcription PCR (qRT-PCR). Results: Low cytotoxic activity and cell internalization of MNP in HeLa and SiHa cells were observed. Lysosomal function was found to be impaired after MNP treatment. Protein tyrosine kinase 2 beta (PTK2B), liprin-alpha-4 (PPFIA4), mothers against decapentaplegic homolog 7 (SMAD7), and interleukin (IL) 1B were identified as key genes relevant for MNP pharmacology, clinical features, somatic mutation, and immune infiltration. The four key genes also exhibited significant correlations with the lysosome gene set. The qRT-PCR results showed significant alterations in the expression of the four key genes after MNP treatment in HeLa and SiHa cells. Conclusion:Our research suggests that treatment of bare MNPs in HeLa and SiHa cells induced significant expression changes in PTK2B, PPFIA4, SMAD7, and IL1B, which play crucial roles in cervical cancer development and progression. Interactions of the key genes with specific anti-cancer drugs must be considered in the rational design of MNP drug delivery systems.

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Tannic acid-induced interfacial ligand-to-metal charge transfer and the phase transformation of Fe3O4 nanoparticles for the photothermal bacteria destruction

Cited by 36 publications

References 78 publications

Laser Synthesized Core-Satellite Fe-Au Nanoparticles for Multimodal In Vivo Imaging and In Vitro Photothermal Therapy

Laser Synthesized Core-Satellite Fe-Au Nanoparticles for Multimodal In Vivo Imaging and In Vitro Photothermal Therapy

Iron oxide@chlorophyll clustered nanoparticles eliminate bladder cancer by photodynamic immunotherapy-initiated ferroptosis and immunostimulation

Systematic Identification of Genomic Markers for Guiding Iron Oxide Nanoparticles in Cervical Cancer Based on Translational Bioinformatics

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