Tannic acid-based metal phenolic networks for bio-applications: a review

Abstract

Tannic acid (TA), a large polyphenolic molecule, has long been known for using in food additive, antioxidants, bio-sorbents, animal feeding and adhesive making due to its intrinsic properties such as...

Tannic Acid–Iron Complex-Based Nanoparticles as a Novel Tool against Oxidative Stress

“… 20 On the other hand, such chelating abilities can be advantageous to prepare more hydrophobic tannic acid–metal complexes with desired properties. 21 , 22 Fe 3+ is usually the preferred metal ion to coordinate tannic acid, thanks to its strong interaction with the ligand, high linkability, and low toxicity as compared to other metal ions that are known to also induce tannic acid cross-linking. 22 , 23 Depending on the pH and concentration, tannic acid–Fe 3+ complexes have very poor solubility in water; 21 thus, they can be easily encapsulated or coated with amphiphilic compounds that can enhance their bioavailability while protecting tannic acid from degradation.…”

“…21 , 22 Fe 3+ is usually the preferred metal ion to coordinate tannic acid, thanks to its strong interaction with the ligand, high linkability, and low toxicity as compared to other metal ions that are known to also induce tannic acid cross-linking. 22 , 23 Depending on the pH and concentration, tannic acid–Fe 3+ complexes have very poor solubility in water; 21 thus, they can be easily encapsulated or coated with amphiphilic compounds that can enhance their bioavailability while protecting tannic acid from degradation. Tannic acid–Fe 3+ or, more in general, tannic acid–metal ion complexes have been proposed for several biological applications, such as cancer therapy, imaging, or wound healing.…”

Polyphenol-based hydrogels: Pyramid evolution from crosslinked structures to biomedical applications and the reverse design

“…Tannic acid (TA) is a naturally plant-derived polyphenol compound that provides the protection of plants from insects, pathogens, and ultraviolet [ 43 ]. The research on functional hydrogels based on TA has also been one of the research hot areas of polyphenol-based hydrogels for several years.…”

Polyphenol-modified nanovesicles for synergistically enhanced in vitro tumor cell targeting and apoptosis

“…However, TA-based nanovesicles in which the periphery is chemically modified for minimizing the toxicity to normal cells by reducing TA toxicity itself and improving injection drug delivery efficiency and therapeutic efficacy have not yet been reported. 22–24…”